Cefuroxime

Adults oral dosing:

• Chronic bronchitis:
  • 250-500mg BD * 7/7
•  Pneumonia:
  • 500mg BD * 5/7
•  URTI , ENT e.g. otitis media, sinusitis, tonsillitis & pharyngitis:
  • 250mg BD *7/7
• UTI :
  • 125mg BD * 5/7
• Pyelonephritis:
  • 250mg BD * 7/7
• Uncomplicated gonorrhea:
  • 1g OD STAT
• Lyme disease:
  • 500mg BD * 14-21 days
• Severe or Complicated Infections:
  • 5 g IV/IM TDS; may be administered QID in life-threatening situations

Children oral dosing:

• 3 months-1 year: 10 mg/kg twice daily (max. per dose 125 mg)
• 2-11 years: 15 mg/kg twice daily (max. per dose 250 mg)
• 12–17 years: 250 mg twice daily, dose may be doubled in severe LRTI or if pneumonia is suspected

With IV/IM use:

• Child: 20 mg/kg every 8 hours (max. per dose 750 mg); increased to 50-60 mg/kg every 6-8 hours for severe infection and cystic fibrosis (max. per dose 1.5 g)
• Adult: 750 mg every 6–8 hours; increased if necessary up to 1.5 g every 6-8 hours for severe infections

In renal impairment:

• CrCl >30 mL/min: No adjustment necessary
• CrCl 10-30 mL/min: Administer usual dose every 24 hours
• CrCl <10 mL/min: Administer usual dose every 48 hours