- Bacterial infections (duration depends on severity):
- IM/IV 1-2g OD OR5-2 g IM/IV BD. Max 4g/24hours.
- Neonate 0-7 days: IM/IV 50-75mg/kg/dose OD
- Children: IM/IV 50-100mg/kg/day OD/BD. Max: 4 g/24h
- Bacterial meningitis:
- IV 4 g/day divided BD/OD *7-21 days
- Children: IV/IM 100mg/kg/day in single daily dose or divided BD x 7-14 days. Max 4g/day.
- Acute bacterial otitis media:
- 50 mg/kg IM once.
- Persistent or treatment failures: IV/IM 50 mg/kg *3/7
- Children 6months-12 years: IM 50 mg/kg in a single dose. Max 1g
- Community-acquired pneumonia:
- Adults: IM/IV 1-2g OD x 5 days minimum
- Children >3 months: IM/IV 50-100 mg/kg/day divided OD/BD x 10/7. Max 2 g/day. May switch to PO regimen when possible to complete course.
- Gonococcal infections:
- Uncomplicated initial or recurrent infection:
- For infections of the pharynx, cervix, urethra or rectum;
- <150 kg: IM 500mg * 1
- >150 kg: IM 1g * 1
- Children <45kg: 25-50 mg/kg/dose IM/IV x 1. Max: 125 mg/dose IM; 250 mg/dose IV
- For infections of the pharynx, cervix, urethra or rectum;
- Uncomplicated initial or recurrent infection:
- Arthritis or arthritis-dermatitis disseminated infection: IM/IV 1g BD *4/52
- May switch to PO treatment according to susceptibility after 24-48h of clinical improvement.
- Use with azithromycin regardless of chlamydia test result.
- Meningitis or endocarditis disseminated infection: IV 1-2 g OD/BD *10-14 days
- Use with azithromycin regardless of chlamydia test result.
- Conjunctivitis: IM/IV 1g * 1
- Use with azithromycin regardless of chlamydia test result.
- Presumptive treatment for sexual assault victims as part of a multi-drug regimen:
- Adolescent and adult females:
- Ceftriaxone 500 mg (OR 1g if weight >150 kg) IM once + Doxycycline 100 mg BD PO * 1/52 + Metronidazole 500 mg PO BD * 1/52
- Adolescent and adult females:
-
- Adolescent and adult males:
- Ceftriaxone 500 mg (OR 1g if weight >150kg) IM once + Doxycycline 100 mg BD PO * 1/52
- Adolescent and adult males:
- For neonates born to mothers with gonococcal infection:
- 25-50 mg/kg/dose IM/IV x 1. Max: 125 mg/dose
- Surgical prophylaxis:
- IV 1g x 1
- Pelvic Inflammatory Disease (PID):
- IM 250 mg as a single dose with doxycycline, with or without metronidazole for 14/7
- Chancroid (Off-label):
- IM 250mg x 1
Injection:
- 2g
- 1g
- 500mg
- 250mg
- IM doses >1g are divided between more than 1 site.
3rd generation cephalosporin with broad-spectrum gram-negative activity.
Inhibits cell-wall synthesis by binding to 1 or more penicillin-binding proteins thus bactericidal.
- Local injection site reaction
- Eosinophilia
- Thrombocytosis
- Elevated ALT/AST
- Clostridium difficile-associated diarrhea
- Glossitis
- Oliguria
- Leukopenia
- Rash
- Severe headaches
- Hypersensitivity to beta-lactam antibiotics
- Neonates <28 days old receiving calcium-containing IV products
- Neonates <28 days old with hyperbilirubinemia
- Neonates <42 weeks postmenstrual age (gestational age + chronological age)
- If patient develops anemia while on ceftriaxone, stop antibiotic until etiology determined
CAUTION:
- Seizure disorders
- Hepatic & renal impairment
- Vit K deficiency
- History of GI disorder
- Aminoglycosides (incompatible)
- Calcium gluconate
- Calcium chloride
- Calcium citrate
- Calcium acetate
- BCG attenuated live vaccine
- Typhoid attenuated live vaccine
- Anticoagulants
- Fluconazole
- Vancomycin
- Amsacrine
Drug Status
| Availability | Prescription only |
| Pregnancy | Category B1; Safe to use |
| Breastfeeding | Safe to use |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Alcizon | 1g | Injection | 1’s | Alembic Pharma | Europa Healthcare |
| Auroxone | 1g | Injection | 1’s | Aurobindo Pharma | Simba Pharma |
| Axone | 1g | Injection | 1’s | Cadila Pharm | Cadila Pharm |
| C Tri | 1g | Injection | 1’s | Emcure Pharma | Lazor Pharma |
| Cefaxone | 1g | Injection | 1’s | Tawwab Pharma | Pharma Specialities |
| Ceftec | 1g | Injection | 1’s | Yeluri Formulations | Europa Healthcare |
| Ceftrimed | 1g | Injection | 1’s | Dawa Ltd | Dawa Ltd |
| Ceftron | 1g | Injection | 1’s | Square Pharma | Ace Pharma |
| Ceftron | 2g | Injection | 1’s | Square Pharma | Ace Pharma |
| Cefzona | 1g | Injection | 1’s | Careplus Ltd | Careplus Ltd |
| Cetafor IM | 1g/4mL | Injection | 1’s | Dafra Pharm | Energia Pharm |
| Cetafor IV | 500mg | Injection | 1’s | Dafra Pharm | Energia Pharm |
| Cetafor IV | 1g | Injection | 1’s | Dafra Pharm | Energia Pharm |
| Da-Oxone | 1g | Injection | 1’s | Dawa Ltd | Dawa Ltd |
| Efectal 1000 | 1g | Injection | 1’s | M/S.Neon Labs | Ripple Pharma |
| Efectal 250 | 250mg | Injection | 1’s | M/S.Neon Labs | Ripple Pharma |
| Eracef | 1g | Injection | 1’s | Brawn Labs | Sai Pharma |
| Eracef | 500mg | Injection | 1’s | Popular Pharma | Madawa Pharma |
| Eracef | 1g | Injection | 1’s | Popular Pharma | Madawa Pharma |
| G-Ceftria | 1g | Injection | 1’s | Guilin Pharma | Tridem Pharma |
| Huacef | 1g | Injection | 1’s | NCPC-Hebei | NCPC-Hebei |
| Imaxone | 1g | Injection | 1’s | Crown Healthcare | Crown Healthcare |
| Injxone | 1g | Injection | 1’s | Surgilinks Ltd. C/O Injectionect Care | Surgilinks Ltd |
| Inno-Ceft | 1g | Injection | 1’s | Innocia Lifesciences | Wessex Pharma |
| Medixone | 1g | Injection | 1’s | Galpha Laboratories Ltd | Medilife Biologicals |
| Mesporin | 2g | Injection | 1’s | Acino Pharma | Goodman Agencies |
| Mesporin IM | 1g | Injection | 1’s | Acino Pharma | Goodman Agencies |
| Mesporin IM | 500mg | Injection | 1’s | Acino Pharma | Goodman Agencies |
| Mesporin IV | 1g | Injection | 1’s | Acino Pharma | Goodman Agencies |
| Mesporin IV | 500mg | Injection | 1’s | Acino Pharma | Goodman Agencies |
| Monotax | 1g | Injection | 1’s | Zydus Healthcare | Sai Pharma |
| Nirixone | 1g | Injection | 1’s | Aculife Healthcare | Crown Healthcare |
| Powercef | 500mg | Injection | 1’s | Wockhardt Ltd | Pharma Specialities |
| Powercef | 1g | Injection | 1’s | Wockhardt Ltd | Pharma Specialities |
| Powercef | 250mg | Injection | 1’s | Wockhardt Ltd | Pharma Specialities |
| Radicef | 500mg | Injection | 1’s | Radiant Pharmaceuticals Ltd. | Radiant pharmaceuticals ltd. |
| Radicef | 1g | Injection | 1’s | Radiant Pharmaceuticals Ltd. | Radiant pharmaceuticals ltd. |
| Rocephin IM | 500mg | Injection | 1’s | F. Hoffman-La Roche | Roche Kenya |
| Rocephin IM | 1g | Injection | 1’s | F. Hoffman-La Roche | Roche Kenya |
| Rocephin IV | 500mg | Injection | 1’s | F. Hoffman-La Roche | Roche Kenya |
| Rocephin IV | 1g | Injection | 1’s | F. Hoffman-La Roche | Roche Kenya |
| Rocephin IV | 2g | Injection | 1’s | F. Hoffman-La Roche | Roche Kenya |
| Safetax | 2g | Injection | 1’s | Synermed Pharma | Synermed Pharma |
| Santriax | 1g | Injection | 1’s | Bliss GVS | Prunus Pharma |
| Sefin | 1g | Injection | 1’s | Galaxy Pharma | Galaxy Pharma |
| Stacef | 1g | Injection | 1’s | Medox Pharma | Medox Pharma |
| Theoxone | 1g | Injection | 1’s | Theon Pharma | Synermed Pharma |
| Torocef | 1g | Injection | 1’s | Torrent Pharma C/O Medox | Medox Pharma |
| Traxef | 1g | Injection | 1’s | CCL Pharma | Harley’s Ltd |
| Triaxone | 1g | Injection | 1’s | Laboratory & Allied | Laboratory & Allied |
| Trixon-1 | 1g | Injection | 1’s | Lincoln Pharma C/O Medox Pharma | Medox Pharma |
| Trox-1 | 1g | Injection | 1’s | Laborate India | Harley’s Ltd |
| Zefone | 1g | Injection | 1’s | Cadila Healthcare | Cadila Healthcare |
| Zoxon | 1g | Injection | 1’s | Sanofi-Aventis | Ressourcethica Kenya |