• Respiratory tract infections
  • Urinary tract infections (upper and lower)
  • Intra-abdominal infections
  • Septicemia
  • Meningitis
  • Skin and soft tissue infections
  • Bone and joint infections
  • Endometritis a
  • Other infections of the genital tract

Dose:

Adults: IV/IM 2-4g (i.e. 1-2g per day cefoperazone) divided BD

Children: IV/IM 40-80mg/kg/day (i.e. 20-40mg/kg/day cefoperazone) in 2 to 4 equally divided doses.

  • Injection:
    • 500mg/500mg
    • 1g/1g
  • None remarkable

Cefoperazone: 3rd generation cephalosporin with broad-spectrum gram-negative activity. Inhibits cell-wall synthesis by binding to 1 or more penicillin-binding proteins thus bactericidal.

Sulbactam: An irreversible inhibitor by covalently binding to β-lactamases, and prevents the enzyme hydrolysis of beta lactams

  • Neutropenia
  • Leukopenia
  • Coombs direct test positive
  • Haemoglobin decreased
  • Haematocrit decreased
  • Thrombocytopenia
  • Hypersensitivity to class or components
  • Anticoagulants
  • Alcohol

                                   Drug Status

Availability Prescription only
Pregnancy Category B; weigh risk vs benefit
Breastfeeding Weigh risk vs benefit
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Alemctum 500mg/500mg Injection 1’s Alembic Pharma Europa Healthcare
Bactacef 1g/1g Injection 1’s Synermed Pharma Synermed Pharma
Cefocel 500mg/500mg Injection 1’s Zawadi Healthcare Zawadi Healthcare
Fytobact 1g/1g Injection 1’s Cadila Pharma Cadila Pharm