• Dysmenorrhea (painful menstruation)
  • Renal colic, biliary colic
  • Spasmodic abdominal pain
  • Postoperative or postpartum uterine cramps
  • Typical Adult Dosage:
    • 1 tablet 2–3 times daily
    • Dosage may vary by formulation and severity of symptoms
  • Drotaverine hydrochloride: 80 mg
  • Mefenamic acid: 250 mg
  • Take after meals with a full glass of water
  • Do not exceed recommended dosage
  • Avoid alcohol and other NSAIDs
  • Drotaverine:
    • Antispasmodic that inhibits phosphodiesterase-4 (PDE-4)
    • Increases cAMP, causing smooth muscle relaxation (GI, uterine, biliary, urinary tracts)
  • Mefenamic Acid:
    • NSAID; inhibits COX enzymes, reducing prostaglandin synthesis
    • Provides analgesic, anti-inflammatory, and antipyretic effects
  • Nausea, vomiting, gastritis
  • Dizziness, headache
  • Abdominal discomfort, diarrhea or constipation
  • Hypersensitivity reactions, especially with mefenamic acid
  • Rare: GI bleeding or renal effects with long-term use
  • Peptic ulcer disease, GI bleeding
  • Renal or hepatic impairment
  • Hypersensitivity to NSAIDs or drotaverine
  • Asthma precipitated by NSAIDs
  • Anticoagulants (e.g., warfarin): ↑ bleeding risk
  • Other NSAIDs: ↑ GI/renal side effects
  • Antihypertensives: possible reduced efficacy
  • Alcohol: ↑ GI irritation

                                   Drug Status

Availability
Pregnancy
Breastfeeding
Schedule
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Spasmocare Plus 80mg/250mg Tablet 30’s Medisel Kenya Medisel Kenya