- Suppression of inflammatory and allergic disorders
- Adult: Maintenance 3–18mg daily
- Suppression of inflammatory and allergic disorders (acute)
- Adult: Initially up to 120mg daily
- Inflammatory and allergic disorders
- Child 1 month–11 years: 0.25–1.5mg/kg OD or on alternate days; increased if necessary up to 2.4mg/kg daily (max. per dose 120 mg) in emergency situations.
-
- Child 12–17 years: 3–18 mg OD or on alternate days; increased if necessary up to 2.4 mg/kg daily (max. per dose 120 mg) in emergency situations.
Tablet:
- 6mg
- 18mg
- 30mg
Suspension:
- 6mg/5mL
- May take with or after food.
- Do not stop taking abruptly without your doctor’s advice.
Corticosteroid prodrug. Oxazaline derivative of prednisolone. 6mg deflazacort has anti-inflammatory potency of about 5mg prednisolone.
Its active metabolite, 21-desDFZ, acts through the glucocorticoid receptor to exert anti-inflammatory and immunosuppressive effects.
It diffuses across cell membranes and forms a complex with specific cytoplasmic receptors. These complexes then enter the cell nucleus, binds to DNA, and stimulate transcription of mRNA which leads to protein synthesis of various enzymes that are responsible for the effects of systemic corticosteroids.
- Cushingoid appearance
- Weight and appetite increase
- Hypertension
- Increased appetite
- Upper RTI
- Cough
- Pollakiuria
- Hypersensitivity reactions
- Muscle mass loss
- Cardiac arrhythmias
- Nasopharyngitis
- Hirsutism
- Central obesity
- Erythema
- Irritability
- Rhinorrhea
- Abdominal discomfort
- Impaired wound healing
- Convulsions
- Spontaneous fractures
- Increased susceptibility to infections
- Growth retardation in children
- Adrenal insufficiency
- Increased blood coagulability
- Masking of infections
- Skin pigmentation
- Immunosuppression
- Insomnia
- Fatigue
- Acne
- Aggravation of pre-existing psychiatric conditions
- Hypersensitivity to the drug
- Systemic fungal infections
- Live vaccines
- Peptic ulceration
- Psychosis
- Osteoporosis
- Severe psychoneurosis
- TB
- Ocular herpes simplex
- Primary glaucoma
- Artemether/lumefantrine
- Carbamazepine
- Chloramphenicol
- Efavirenz
- Fosphenytoin
- Nevirapine
- Phenobarbital
- Phenytoin
- Quinidine
- Rifabutin
Drug Status
| Availability | Prescription or OTC by Pharmacist |
| Pregnancy | Category C; Contraindicated |
| Breastfeeding | Contraindicated; can cause growth retardation in neonates |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Cozecort | 30mg | Tablet | 60’s | Medisel Kenya | Medisel Kenya |
| Cozecort | 6mg | Tablet | 60’s | Medisel Kenya | Medisel Kenya |
| Cozecort | 6mg/5mL | Suspension | 30mL | Medisel Kenya | Medisel Kenya |
| Defcian | 6mg | Tablet | 10’s | Cian Health Care | Cian Health Care |
| Deflaz | 6mg/5mL | Suspension | 30’s | Zuvan Limited | Zuvan Limited |
| Dynacort | 6mg/5mL | Suspension | 100mL | Galaxy Pharma | Galaxy Pharma |
| Deflozed | 6mg | Tablet | 10’s | Zawadi Healthcare | Zawadi Healthcare |
| Dynacort | 6mg | Tablet | 30’s | Galaxy Pharma | Galaxy Pharma |
| Dynacort | 18mg | Tablet | 30’s | Galaxy Pharma | Galaxy Pharma |
| Dynacort | 30mg | Tablet | 30’s | Galaxy Pharma | Galaxy Pharma |
| Yescort | 6mg | Tablet | 30’s | Surgilinks Ltd C/O Yash Pharma | Surgilinks Ltd |
| Yescort | 30mg | Tablet | 30’s | Surgilinks Ltd C/O Yash Pharma | Surgilinks Ltd |