- General anesthesia induction:
- Healthy adults <55 years:
- IV 2-2.5mg/kg/dose given as 40mg every 10 sec until induction onset
- IV 2-2.5mg/kg/dose given as 40mg every 10 sec until induction onset
- Healthy adults <55 years:
-
- >55 years/debilitated:
- IV 1-1.5mg/kg/dose given as 20mg every 10 sec until induction onset
- IV 1-1.5mg/kg/dose given as 20mg every 10 sec until induction onset
- >55 years/debilitated:
-
- Neurosurgical patients:
- IV 1-2mg/kg/dose given as 20mg every 10 sec until induction onset
- IV 1-2mg/kg/dose given as 20mg every 10 sec until induction onset
- Neurosurgical patients:
-
- Cardiac anesthesia patients:
- IV 0.5-1.5mg/kg/dose given as 20mg every 10sec until induction onset
- IV 0.5-1.5mg/kg/dose given as 20mg every 10sec until induction onset
- Cardiac anesthesia patients:
-
- Children (3-16 years):
- IV 2.5-3.5mg/kg/dose *1
- IV 2.5-3.5mg/kg/dose *1
- Children (3-16 years):
- Maintenance of general anesthesia:
- Healthy adults <55 years:
- IV 100-200mcg/kg/min OR 25-50mg PRN
- IV 100-200mcg/kg/min OR 25-50mg PRN
- Healthy adults <55 years:
-
- >55 years/debilitated:
- IV 50-100mcg/kg/min
- IV 50-100mcg/kg/min
- >55 years/debilitated:
-
- Neurosurgical patients:
- IV 100-200mcg/kg/min
- IV 100-200mcg/kg/min
- Neurosurgical patients:
- Cardiac anesthesia patients:
- IV 100-150mcg/kg/min
- Decrease dose to 50-100mcg/kg/min if used as secondary agent
-
- Children (2 months-16 years):
- IV 125-300mcg/kg/min
- Children (2 months-16 years):
- Monitored anesthesia care:
- Induction:
- IV 100-150mcg/kg/min *3-5min OR IV 0.5mg/kg/dose *1
- IV 100-150mcg/kg/min *3-5min OR IV 0.5mg/kg/dose *1
- Induction:
-
- Maintenance:
- IV 25-75mcg/kg/min OR IV 10-20mg PRN
- Avoid bolus doses and reduce dose 20% in elderly, debilitated or neurosurgical patients
- Maintenance:
- ICU sedation:
- IV 5mcg/kg/min *5min, then may increase by 5-10mcg/kg/min every 5-10min
- Allow a minimum of 5 min between adjustments for onset of peak effect
- Allow a minimum of 5 min between adjustments for onset of peak effect
- IV 5mcg/kg/min *5min, then may increase by 5-10mcg/kg/min every 5-10min
-
- Maintenance: 5-50mcg/kg/min
Injection: 1% w/v
- To reduce pain associated with injection, use larger veins of forearm or antecubital fossa; lidocaine IV (1mL of a 1% solution) may also be used prior to administration
Short-acting, lipophilic sedative/hypnotic general anesthetic
It is thought to causes global CNS depression through agonist actions on GABA receptors
- Injection site reaction
- Hypotension
- Involuntary muscle movements
- Respiratory acidosis during weaning
- Hyperlipidemia
- Rash
- Pruritus
- Hypersensitivity to class/components
- Hypersensitivity to soybean or egg product
- Labour and delivery
- Abrupt withdrawal
- Mavacamten
Drug Status
Availability | Prescription only |
Pregnancy | Category B |
Breastfeeding | Unknown; Weigh risk vs benefit |
Schedule | Not controlled |
BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
---|---|---|---|---|---|
Diprivan | 1% w/v | Injection | 50mL | Fresenius Kabi | Surgipharm Ltd |
Diprivan | 2% w/v | Injection | 50mL | Fresenius Kabi | Surgipharm Ltd |
Nirfol 1% | 1% w/v | Injection | 20mL | Aculife Healthcare | Crown Healthcare |
Pofol Lnjection | 2% w/v | Injection | 5’s | Popular Pharma | Madawa Pharma |
Propofol | 1% w/v | Injection | 20mL | Galaxy Pharma | Galaxy Pharma |
Propofol Fresenius | 1% w/v | Injection | 20mL | Fresenius Kabi | Surgipharm Ltd |
Propofol-Lipuro | 1% w/v | Injection | 100mL | B. Braun Melsungen | B.Braun Medical |
Provive | 1% w/v | Injection | 20mL | Elda International | Reddys Pharma |
Troypofol | 1% w/v | Injection | 20mL, 50mL | Troikaa | Harley’s Ltd |