• Anaesthesia adjunct:
    • Preoperative: IM 4mcg/kg 30-60 min before surgery
      • For reduction of secretions
    • Intraoperative: IV 0.1mg
      • May repeat every 2-3min
      • For reversal of bradycardia, vagal reflexes
  • Neuromuscular blockade reversal:
    • IV 0.2mg IV per 1mg of neostigmine or 5mg of pyridostigmine administered
  • Adjunct to treatment of peptic ulcer:
    • PO 1-2mg BD/TDS
      • Start: PO 1mg TDS
      • Max: 8mg/day
    • IM/IV 0.1-0.2mg TDS/QID
      • Max: 0.8mg/day
      • Space doses 4 hrs apart
  • Antisialogogue (Off-label):
    • PO 1-2mg BD/TDS PRN
      • Max: 8mg/day
      • Injectable product may be given PO
    • SC/IM/IV 0.1-0.2mg every 4-8 hrs PRN
      • Max: 0.8mg/day
  • Hyperhidrosis (Off-label)
    • PO 1-2mg BD/TDS PRN
      • Start: PO 1mg BD
      • Max: 8 mg/day
  • Drooling (Off-label)
    • PO 0.1mg/kg BD/TDS
    • Max 8mg/day
  • Injection:
    • 2mg/mL
  • Tablet:
    • 1mg
    • 2mg
  • High fat food reduces PO bioavailability
  • Administer IV at a rate of 0.2mg over 1-2 min

Anticholinergic (antimuscarinic) agent

It inhibits the action of acetylcholine on structures innervated by postganglionic cholinergic nerves and on smooth muscles that respond to acetylcholine but lack cholinergic innervation.

  • Xerostomia
  • Vomiting
  • Constipation
  • Flushing
  • Nasal congestion
  • Headache
  • Sinusitis
  • URI
  • Urinary retention
  • Drowsiness
  • Photophobia
  • Lactation suppression
  • Hypersensitivity to drug or ingredient
  • Neonates (benzyl alcohol-containing inj form)
  • Angle-closure glaucoma
  • Myasthenia gravis
  • Obstructive uropathy
  • Acute hemorrhage with unstable cardiovascular status
  • GI ulcer or bleeding
  • GI obstruction
  • GI motility disorder
  • Intestinal atony (elderly or debilitated pts)
  • Paralytic ileus
  • Toxic megacolon
  • Toxic megacolon history
  • Inflammatory or infectious colitis
  • Potassium chloride
  • Potassium citrate
  • Umeclidinium bromide/vilanterol inhaled

                                   Drug Status

Availability Prescription only
Pregnancy Weigh risk vs benefit
Breastfeeding Weigh risk vs benefit; may cause lactation suppression
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Glycopyrronium Bromide 200mcg/mL Injection 10’s Macarthys Labs Laborex Kenya