Tramadol

• Tablet/Capsule:
  • 50mg
  • 100mg

• Injection:
  • 100mg/2mL
  • 100mg/mL
  • 50mg/mL
  • 50mg/2mL

• NOT recommended <12 years.
• Round dose down to nearest 100 mg
• Assess need for naloxone when renewing treatment
• NOT to be used with other tramadol-containing products

Opioid analgesic

It is a centrally acting analgesic with binding to specific opioid receptors.  It is a non-selective pure agonist at mu, delta and kappa receptors but with a higher affinity for mu receptors.

It may also inhibit the neuronal re-uptake of noradrenaline and serotonin.

• Dizziness
• Nausea
• Somnolence
• Headaches
• Dry mouth
• Constipation
• Urinary retention
• Sweating
• Fatigue
• Respiratory depression
• Serotonin syndrome
• Dependency
• Syncope
• Orthostatic hypotension

• Hypersensitivity to compound or other opioids
• Acute intoxication with alcohol, hypnotics, analgesics, opioids or psychotropic drugs
• Narcotic withdrawal treatment
• Patients 12-18 years with risk of respiratory depression
• Electrolyte abnormalities
• Acute asthma
• Suicidal behavior
• Circulatory shock
• Coma/impaired consciousness
• MAOI use within 14 days
• Postoperative management in children <18 years following tonsillectomy and/or adenoidectomy

• MAOIs
• Quinidine
• Carbamazepine
• Fluconazole
• Isoniazid
• Antipsychotics
• CNS depressants