• Moderate to severe acute pain in adults.
  • Management of chronic pain that requires around-the-clock treatment and when other pain medications are inadequate.
  • Neuropathic pain associated with diabetic peripheral neuropathy in adults.

Dose:

  • Acute pain:
    • Initial dose: PO 50-100 mg every 4-6 hours as needed.
    • Max daily dose: 600mg
  • Chronic Pain/Neuropathic pain:
    • Initial dose: PO 50mg BD titrating based on patient response.
    • Max daily dose: 500mg.

Tablet:

  • 100mg
  • 200mg
  • Can be taken with or without food

Centrally acting analgesic with two mechanisms of action: mu-opioid receptor agonism and norepinephrine reuptake inhibition. This dual mechanism helps relieve moderate to severe pain by both opioid and non-opioid pathways.

  • Nausea
  • Vomiting
  • Constipation
  • Drowsiness
  • Dizziness
  • Headache
  • Severe respiratory depression or acute asthma.
  • Paralytic ileus
  • Hypersensitivity to tapentadol or its excipients.
  • Concurrent use with MAO inhibitors (within the last 14 days).
  • CNS depressants
  • MAO inhibitors

                          Drug Status

Availability Prescription only
Pregnancy Not recommended
Breastfeeding Use with caution
Schedule Controlled