• Ankylosing spondylitis, osteoarthritis, rheumatoid arthritis requiring ulcer prophylaxis:
    • PO 1 tab BD
  • Tablet:
    • 500mg/20mg
  • Taken 30 min before meals

Naproxen: NSAID. It inhibits COX 1 & 2 reducing prostaglandin and thromboxane synthesis.

Esomeprazole: Proton pump inhibitor. It suppresses gastric acid secretion by specific inhibition of the H+/K+ ATPase enzyme system at the secretory surface of gastric parietal cells. It inhibits the proton pump, the final step in gastric acid secretion

  • Gastritis
  • Diarrhea
  • Abdominal pain
  • Constipation
  • Flatulence
  • Dizziness
  • Peripheral edema
  • Headache
  • Dyspepsia
  • Gastric ulcer
  • Nausea
  • Drowsiness
  • Rash
  • Elevated ALT/AST
  • Tinnitus
  • Ecchymosis
  • Dyspnea
  • Photosensitivity
  • Delayed ovulation
  • Vitamin b12 deficiency (long-term use)
  • Fundic gland polyps (long-term use)
  • Children <18 years
  • Asthma
  • Breastfeeding
  • Aspirin triad
  • Cerebrovascular haemorrhage
  • GI perforation and haemorrhage
  • Haematological disorder
  • Peptic ulcer
  • Renal impairment; CrCl <30mL/min
  • Severe cardiac failure
  • Severe hepatic impairment
  • Third trimester of pregnancy
  • Ketorolac
  • Rilpivirine

                                   Drug Status

Availability Prescription only
Pregnancy Contraindicated
Breastfeeding Contraindicated
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Prezola 500mg/20mg Tablet 30’s Medisel Kenya Medisel Kenya