- Opioid dependence:
- Short-term detox: PO 20-30mg *1, then 5-10mg every 2-4 hours PRN
- Max: 30mg/initial dose, 40mg on day 1
- Stabilize dose *2-3 days, then decrease dose by up to 20% every 24-48 hours
- Short-term detox: PO 20-30mg *1, then 5-10mg every 2-4 hours PRN
-
- Maintenance treatment: PO 20-30mg *1, then 5-10mg every 2-4 hours PRN
- Max: 30mg/initial dose, 40mg on day 1
- Maintenance treatment: PO 20-30mg *1, then 5-10mg every 2-4 hours PRN
- Moderate-severe chronic pain:
- Parenteral route in opioid-naive patients: Individualize dose SC/IM/IV BD/TDS
- Initially SC/IM/IV 2.5mg every 8-12 hours
- Parenteral route in opioid-experienced patients: individualize dose SC/IM/IV QID/TDS
- Parenteral route in opioid-naive patients: Individualize dose SC/IM/IV BD/TDS
Injection: 5mg/mL
- Consider increasing dose or frequency in pregnant patients
Opioid analgesic
It inhibits ascending pain pathways, thus altering perception and response to pain. It produces analgesia, respiratory depression and sedation
- Lightheadedness
- Dizziness
- Sedation
- Nausea
- Vomiting
- Diaphoresis
- Constipation
- Decreased ejaculate volume
- Sperm abnormalities
- Hypersensitivity to components
- MAO inhibitor use within 14 days
- Severe respiratory depression
- Acute and severe asthma
- Known or suspected GI obstruction
- Paralytic ileus
- Coma
- Impaired consciousness
- Circulatory shock
WARNING:
- Risk of opioid addiction, abuse and misuse, which can lead to overdose and death
- QT interval prolongation and serious arrhythmia (torsades de pointes) have occurred
- Prolonged use during pregnancy can result in neonatal opioid withdrawal syndrome
- Serious, life-threatening or fatal respiratory depression may occur
- Cisapride
- Dronedarone
- Eliglustat
- Itraconazole
- Ketoconazole
- Levoketoconazole
- Naltrexone
- Pimozide
- Posaconazole
- Quinidine
- Rasagiline
- Safinamide
- Samidorphan
- Selegiline
- Thioridazine
- Ziprasidone
Drug Status
| Availability | Prescription only |
| Pregnancy | Category C |
| Breastfeeding | Weigh risk vs benefit |
| Schedule | Controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Column 1 Value | Column 2 Value | Column 3 Value | Column 4 Value | Column 5 Value | Column 6 Value |