- Osteoarthritis/rheumatoid arthritis:
- Adult: PO 200mg-800mg TDS/QID
- Max: 3200mg/day
- Children <11 years: PO 30-40 mg/kg/day PO divided QID
- Dysmenorrhea:
- Adult: PO 400mg every 4-6 hours PRN
- Max: 3200 mg/day
- Mild-moderate pain:
- Adult and >12 years: PO 400mg every 4-6 hours PRN
- 6 months- 11 years: PO 5-10mg/kg/dose every 6-8 hours PRN. Max: 40mg/kg/day
- Fever:
- Adult and >12 years: PO 200mg-400mg every 4-6 hours PRN
- Anti-inflammatory:
- PO 600mg QID *7-14 days
- Max: 2400mg/day
- Tablet:
- 200mg
- 400mg
- Suspension:
- 200mg/5mL
Taken with food
NSAID
It inhibits COX-1 and COX-2 reducing prostaglandin and thromboxane synthesis
- Dyspepsia
- Nausea
- Abdominal pain
- Constipation
- Headache
- Dizziness
- Drowsiness
- Rash
- Elevated ALT/AST
- Fluid retention
- Tinnitus
- Ecchymosis
- Photosensitivity
- Delayed ovulation
- Hypersensitivity to drug, other NSAIDs, aspirin or components
- Perioperative pain in setting of coronary artery bypass graft (CABG) surgery
- Aspirin/NSAID-induced urticaria or asthma
- Aspirin triad
- CrCl <30
- Advanced renal disease
- Can cause premature closure of fetal ductus arteriosus and fetal renal dysfunction leading to oligohydramnios and, in some cases, neonatal renal impairment
WARNING:
- Increased risk of serious and potentially fatal cardiovascular thrombotic events, including MI and stroke
- Increased risk of serious and potentially fatal GI adverse events including bleeding, ulceration and stomach or intestine perforation
- Ketorolac
Drug Status
| Availability | OTC |
| Pregnancy | Contraindicated |
| Breastfeeding | Can be used |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Betafen | 100mg/5mL | Suspension | 60mL, 100mL | Beta Healthcare | Beta Healthcare |
| Brufen | 100mg/5mL | Suspension | 100mL | Abbott Labs | Harley’s Ltd |
| Brufen Retard | 800mg | Tablet | 60’s | Abbott Labs | Harley’s Ltd |
| Brufol | 400mg | Tablet | 100’s | Careplus Ltd | Careplus Ltd |
| Daprofen | 100mg/5mL | Suspension | 60mL, 100mL | Dawa Ltd | Dawa Ltd |
| Fenpro | 200mg | Tablet | 100’s | Dinlas Pharma | Dinlas Pharma |
| Fenpro | 100mg/5mL | Suspension | 60mL, 100mL | Dinlas Pharma | Dinlas Pharma |
| Gofen | 200mg | Capsule | 60’s | Mega Life Sciences | Mega Life Sciences |
| Gofen | 400mg | Capsule | 60’s | Mega Lifesciences | Mega Lifesciences |
| Ibu | 200mg | Tablet | 100’s | Pharma Life Science | Pharma Life Science |
| Ibu | 400mg | Tablet | 100’s | Pharma Life Science | Pharma Life Science |
| Ibucos | 200mg | Tablet | 100’s | Cosmos Ltd | Cosmos Ltd |
| Ibucos | 400mg | Tablet | 100’s | Cosmos Ltd | Cosmos Ltd |
| Ibucos | 100mg/5mL | Suspension | 100mL | Cosmos Ltd | Cosmos Ltd |
| Ibufen | 100mg/5mL | Suspension | 60mL, 100mL | Elys Chemicals | Elys Chemicals |
| Ibufen | 400mg | Tablet | 100’s | Elys Chemicals | Elys Chemicals |
| Ibufen | 200mg | Tablet | 100’s | Elys Chemicals | Elys Chemicals |
| Ibufil | 200mg | Tablet | 100’s | Fourrts Labs | Sai Pharma |
| Ibufil | 400mg | Tablet | 100’s | Fourrts Labs | Sai Pharma |
| Ibuflam | 400mg | Tablet | 100’s, 500’s | Biodeal Labs | Biodeal Labs |
| Ibuflam | 200mg | Tablet | 100’s, 1000’s | Biodeal Labs | Biodeal Labs |
| Ibuflam | 100mg/5mL | Suspension | 60mL, 100mL | Biodeal Labs | Biodeal Labs |
| Ibumex | 5% w/w | Gel | 25g | Regal Pharma | Regal Pharma |
| Ibumex | 100mg/5mL | Suspension | 60mL, 100mL | Regal Pharma | Regal Pharma |
| Ibumex | 200mg | Tablet | 100’s | Regal Pharma | Regal Pharma |
| Ibumex | 400mg | Tablet | 100’s | Regal Pharma | Regal Pharma |
| Ibun | 400mg | Tablet | 100’s | Lincoln Pharma C/O Medox Pharma | Medox Pharma |
| Ibun | 200mg | Tablet | 100’s | Lincoln Pharma C/O Medox Pharma | Medox Pharma |
| Ibuprofen Denk | 400mg | Tablet | 100’s | Denk Pharma | Laborex Kenya |
| Ibuprofen Denk | 600mg | Tablet | 20’s | Denk Pharma | Laborex Kenya |
| Ibut | 200mg | Tablet | 100’s | Leben Labs | Unisel Ltd |
| Ibut | 400mg | Tablet | 100’s | Leben Labs | Unisel Ltd |
| Ibutab | 200mg | Tablet | 100’s | Universal Corporation | Universal Corporation |
| Ibutab | 400mg | Tablet | 100’s | Universal Corporation | Universal Corporation |
| Ibux | 100mg/5mL | Suspension | 60mL | Biopharma Ltd | Biopharma Ltd |
| Ifen | 200mg | Tablet | 100’s, 1000’s | Zest Pharma | Synermed Pharma |
| Ifen | 400mg | Tablet | 100’s, 500’s | Zest Pharma | Synermed Pharma |
| Medifen | 400mg | Tablet | 100’s | Medico Remedies | Harley’s Ltd |
| Mediprofen | 100mg/5mL | Suspension | 60mL, 100mL | Medivet Products | Medivet products ltd |
| Neoprofane | 200mg | Tablet | 100’s | Crown Healthcare | Crown Healthcare |
| Orbifen | 100mg/5mL | Suspension | 100mL | Sai Pharma | Sai Pharma |
| Pedifen | 100mg/5mL | Suspension | 100mL | Dafra Pharm | Energia Pharm |
| Pedifen | 400mg | Tablet | 30’s | Dafra Pharm | Energia Pharm |
| Ponafen | 100mg/5mL | Suspension | 60mL, 100mL | Sphinx Pharma | Sphinx Pharma |
| Profen | 200mg | Tablet | 100’s, 1000’s | Laboratory & Allied | Laboratory & Allied |
| Profen | 400mg | Tablet | 100’s, 500’s | Laboratory & Allied | Laboratory & Allied |
| Profen | 100mg/5mL | Suspension | 60mL, 100mL | Laboratory & Allied | Laboratory & Allied |
| Simfen | 200mg | Tablet | 100’s | Galentic Pharma | Avacare Kenya |