Caffeine/ Codeine/ Doxylamine/ Paracetamol

• Caffeine-45mg/50mg
• Codeine-10mg
• Doxylamine-5mg
• Paracetamol-450mg

• Should NOT be used for more than 10 days without a doctor’s consultation.
• Use for more than 3 days can lead to dependency and addiction.
• Avoided in children below 12 years.

Caffeine: Has vasoconstrictive properties which can help when treating vascular headaches

Codeine: Opioid agonist; analgesia. It blocks pain impulse generation and inhibits ascending pain pathways, thus altering the perception and response to pain.

Doxylamine: 1^st generation antihistamine. Has sedative and antihistaminic action and provides relief in tension states when combined with codeine and paracetamol. It antagonizes the effects of histamine in the uterus, GI tract, large blood vessels and bronchial muscles

Paracetamol: Non-opioid, non-salicylate analgesic. It inhibits prostaglandin synthesis in CNS and may block peripheral pain impulse generation. Antipyretic activity as it acts on the hypothalamus as well.

’t tolerate aspirin e.g. patients on steroid therapy, acute & chronic gastritis, PUD and those with aspirin sensitivity.

• Nausea and vomiting
• Constipation
• Insomnia
• Irritability
• Headaches
• Drowsiness
• Dry mouth
• Sweating
• Facial flushing
• Hypotension
• Vertigo
• Bradycardia

• Respiratory depression especially in presence of cyanosis and excessive bronchial secretions.
• Severe liver function impairment
• Peptic ulcers
• Alcoholism
• Head injuries
• High intracranial pressure
• Bronchial asthma
• Heart failure secondary to chronic lung disease
• Concomitant use with MAO inhibitors

WARNING

• Should NOT be used for more than 10 days without a doctor’s consultation.
• Use for more than 3 days can lead to dependency and addiction.
• Avoided in children below 12 years.

May cause drowsiness and impaired concentration that can be aggravated by simultaneous intake of alcohol or other CNS depressants.