• Used for the relief of productive (wet) cough, chest congestion, and allergic symptoms such as runny nose, sneezing, and postnasal drip. Commonly prescribed in bronchitis, upper respiratory infections, and cold-related cough
  • DOSAGE   
  • Adults: PO  5–10 mL every 8 hours
  • Children 6–12 years: PO  2.5–5 mL every 8 hours
  • Children 2–6 years: 2.5 mL every 8 hours (with caution)
     (Not recommended under 2 years without medical supervision)
  • Ammonium chloride: 60–100 mg
  • Bromhexine HCl: 4 mg
  • Promethazine HCl: 2.5–5 mg
    (Exact strengths may vary by brand/formulation)
  • Shake well before use
  • Take after meals to minimize gastric irritation
  • Use a dosing syringe or spoon for accurate measurement
  • Avoid alcohol and sedatives
  • Stay well hydrated to aid mucus clearance
  • Ammonium Chloride: Acts as an expectorant by irritating the respiratory mucosa, leading to increased respiratory secretions.
  • Bromhexine: A mucolytic agent that reduces the viscosity of mucus, helping in easier expectoration.
  • Promethazine:A first-generation antihistamine with anticholinergic, sedative, and antiemetic properties; helps relieve allergy-related symptoms.
  • Ammonium Chloride: GI irritation, nausea, vomiting (in high doses)
  • Bromhexine: Nausea, vomiting, gastric discomfort, headache
  • Promethazine: Drowsiness, dry mouth, dizziness, blurred vision, constipation, urinary retention
  • Hypersensitivity to any component
  • Severe liver or kidney dysfunction
  • Narrow-angle glaucoma
  • Children under 2 years (risk of respiratory depression from promethazine)
  • Patients with acute asthma or lower respiratory tract infections (use promethazine cautiously)
  • CNS depressants (e.g., alcohol, sedatives): May increase drowsiness with promethazine
  • Anticholinergic agents: Additive effects with promethazine
  • MAO inhibitors: Avoid use with promethazine due to increased risk of adverse CNS effects
  • Antitussives: May counteract the expectorant effect

                                   Drug Status

Availability OVER THE COUNTER
Pregnancy Bromhexine: Generally considered safe in second and third trimesters
Breastfeeding
  • Not generally recommended
Schedule NO
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Koosil Expectorant 100mg/2mg/4mg per 5mL Suspension 100mL Dawa Ltd Dawa Ltd