Nebivolol/ Hydrochlorothiazide

Tablet:

• 5mg/12.5mg
• 5mg/25mg

• Taken without regards to meals
• It can mask symptoms of high blood sugar
• May cause dehydration therefore advised to take with a lot of water

Nebivolol: Cardioselective beta-blocker. It maintains or improves left ventricular function in healthy subjects and in patients with hypertension by decreasing heart rate, increasing cardiac output and stroke volume. In also protects health by reducing oxidative stress and increasing nitric oxide bioavailability through non-receptor dependent scavenging of O2- and β,3-adrenergic receptor-dependent inhibition of NADPH oxidase and endothelial nitric oxide synthase uncoupling

Hydrochlorothiazide: Thiazide diuretic. It inhibits sodium reabsorption in distal renal tubules, resulting in increased excretion of water and of sodium, potassium and hydrogen ions.

• Diarrhea
• Dizziness
• Headache
• Paresthesia
• Decreased potassium level in the blood
• Increased blood uric acid
• Altered blood lipid level
• Breathlessness
• Swelling of hands & feet
• Decreased magnesium level in the blood
• Increased calcium level in the blood

• Liver function impairment
• Anuria
• Cardiovascular diseases
• Hypotension
• Bronchospasm
• Abnormal levels of potassium, calcium and sodium
• Symptomatic hyperuricemia

• Cholecalciferol (D3)
• Tizanidine