- Candidemia, acute disseminated candidiasis, candida peritonitis and abscesses:
- Adults:
- IV 100mg/day *10-47 days (mean 15 days)
- IV 100mg/day *10-47 days (mean 15 days)
- Adults:
-
- Children
- ≥4 months: IV 2mg/kg OD; not to exceed 100 mg/day
- <4 months: IV 4mg/kg OD
- Children
- Esophageal candidiasis:
- Adults:
- IV 150 mg/day *10-30 days (mean 15 days)
- IV 150 mg/day *10-30 days (mean 15 days)
- Adults:
-
- Children:
- ≤30 kg: IV 3mg/kg OD
- >30 kg: IV 2.5mg/kg OD; not to exceed 150mg/day
- Children:
- Prophylaxis of candida Infections in stem cell transplant:
- Adults:
- IV 50mg/day *6-51 days (mean 19 days)
- IV 50mg/day *6-51 days (mean 19 days)
- Adults:
-
- Children:
- ≥4 months: IV 1mg/kg OD; not to exceed 50mg/day
- ≥4 months: IV 1mg/kg OD; not to exceed 50mg/day
- Children:
- Oropharyngeal candidiasis (Off-label):
- IV 100mg OD
- For fluconazole-refractory disease
- For fluconazole-refractory disease
- IV 100mg OD
- Candidal endocarditis (Off-label):
- IV 150mg OD
- For native valve endocarditis
- Not 1st-line agent
- IV 150mg OD
- Febrile neutropenia (Off-label):
- IV 100-150mg OD
- For empiric treatment in high-risk patients with persistent fever
- IV 100-150mg OD
- Injection:
- 50mg
- 100mg
- Do not shake the medication bottle
- After mixing this medicine, do not expose it to light.
- Cover the IV bag during your infusion to protect the medicine from light.
- Use the medicine within 24 hours after mixing
- Do not mix with other medicine in the same IV line
- Flush existing infusion line with 0.9% NaCl before administration
- Infuse IV over 1 hr
Echinocandin antifungal
It inhibits synthesis of 1,3-beta-D-glucan, inhibiting fungal cell wall synthesis
- Diarrhea
- Nausea
- Vomiting
- Fever
- Headache
- Thrombocytopenia
- Neutropenia
- Anemia (peds pts)
- Insomnia
- Abdominal pain
- Rash
- Tachycardia
- Anxiety
- Pruritus (peds pts)
- Urticaria (peds pts)
- Hyperglycemia (peds pts)
- Epistaxis (peds pts)
- Injection site reaction
- Infusion site reaction
- Elevated ALT/AST
- Elevated Alk phos
- Increased BUN or Cr
- Hypernatremia
- Hypoglycemia
- Hyperkalemia
- Hypokalemia
- Hypocalcemia (peds pts)
- HTN (peds pts)
- Hypersensitivity to class/components
- Pregnancy
- None restricted
Drug Status
| Availability | Prescription only |
| Pregnancy | Contraindicated |
| Breastfeeding | Weigh risk vs benefit |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Mycamine | 50mg | Injection | 1’s | Astellas Pharma | Harley’s Ltd |
| Mycamine | 100mg | Injection | 1’s | Astellas Pharma | Harley’s Ltd |