- HIV infection:
- PO 1 tab OD *14/7 with 1 tab OD lamivudine/zidovudine after 12 hours, then 1 tab BD
- Tablet:
- 150mg/200mg/300mg
- Taken on an empty stomach, preferably at bedtime, to reduce side effects
Lamivudine: NRTI (cytosine analog). It inhibits HIV reverse transcriptase by viral DNA chain termination.
Nevirapine: NNRTI. It inhibits reverse transcriptase and incorporates into viral DNA resulting in DNA chain termination
Zidovudine: NRTI. It inhibits reverse transcriptase and incorporates into viral DNA, resulting in DNA chain termination
- Nausea
- Vomiting
- Diarrhea
- Headache
- Tiredness
- Insomnia
- Rash
- Muscle damage
- Anemia
- Decreased white blood cell count (neutrophils)
- Chills and fever
- Indigestion
- Difficulty with bowel movements
- Hypersensitivity to drug or ingredient
- Hepatic impairment
- Impaired renal function
- Lactation
- Neutropenia
- Pregnancy
WARNING
- Risk of:
- Hepatotoxicity
- Skin reactions
- Hematologic toxicity
- Myopathy
- Lactic acidosis
- Severe hepatomegaly with steatosis
- Exacerbations of hepatitis B
- Efavirenz
- Indinavir
- Ritonavir
- Chloramphenicol
- Carbamazepine
- Fluconazole
- Ketoconazole
- Ganciclovir
- Lopinavir
Drug Status
| Availability | Prescription only |
| Pregnancy | Contraindicated |
| Breastfeeding | Contraindicated |
| Schedule | Not scheduled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Lazidariv-N | 150mg/200mg/300mg | Tablet | 60’s | Cosmos Ltd | Cosmos Ltd |