• Rheumatoid Arthritis (RA) – with methotrexate

Dose:3 mg/kg IV at 0, 2, and 6 weeks, then every 8 weeks,dose may be increased to 10 mg/kg

  • Crohn’s Disease (adult & pediatric) – moderate to severe, refractory cases
  • Ulcerative Colitis (UC) – moderate to severe

Dose:5 mg/kg IV at 0, 2, and 6 weeks, then every 8 weeks,May increase to 10 mg/kg for loss of response

  • Ankylosing Spondylitis (AS)

  • Psoriatic Arthritis (PsA)

Dose:5 mg/kg IV at 0, 2, and 6 weeks, then every 6–8 weeks

  • Plaque Psoriasis – moderate to severe

Dose:5 mg/kg IV at 0, 2, and 6 weeks, then every 8 weeks

  • Lyophilized powder: 100 mg per vial
  • Reconstituted with sterile water, infused over 2+ hours
  • Not administered subcutaneously
  • IV infusion only, given under medical supervision
  • Monitor vital signs during and after infusion
  • Observe patients for 1–2 hours post-infusion (especially first few doses) for signs of hypersensitivity
  • Class: Chimeric monoclonal antibody (IgG1) against TNF-α
  • Mechanism of Action:
    • Binds soluble and transmembrane TNF-α → inhibits inflammation, cell recruitment, cytokine release
    • Reduces signs and symptoms of autoimmune diseases
  • Half-life: ~8–10 days
  • Immunogenicity: Formation of anti-drug antibodies may reduce efficacy and increase infusion reactions
  • Infusion-related reactions: fever, chills, itching, headache
  • Respiratory infections (e.g., sinusitis, bronchitis)
  • Abdominal pain, nausea
  • Fatigue
  • Hypersensitivity to infliximab or murine proteins
  • Moderate to severe heart failure (NYHA III/IV) at doses >5 mg/kg
  • Active severe infection (e.g., sepsis, abscesses, TB)
  • Live vaccines: Avoid during and after treatment
  • Combined use with anakinra or abatacept is not recommended
  • Immunosuppressants: ↑ risk of infection
  • Caution with other biologics

                                   Drug Status

Availability
Pregnancy
Breastfeeding
Schedule
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Remicade 100mg Injection 1’s Janssen Pharma Surgipharm Ltd