- Angina:
- PO 1-2 spray(s) PRN for angina
- May repeat every 3-5min
- Max 3 sprays in 15 minutes
- Prophylaxis in angina:
- PO 1-2 sprays 5-10 minutes before activities likely to cause angina
Spray:
- 0.4mg/dose
- Spray onto or under tongue
- Do not inhale, expectorate or rinse mouth for 5-10 minutes
Organic nitrate
It causes systemic venodilation, decreasing preload. The nitrate enters vascular smooth muscle and is converted to nitric oxide (NO) leading to production of cGMP & vasodilation. It relaxes smooth muscle via dose-dependent dilation of arterial and venous beds to reduce both preload and afterload, and myocardial oxygen demand
- Dizziness
- Headache
- Increased heart rate
- Flushing
- Weakness
- Hypersensitivity
- Acute myocardial infarction
- Severe anemia
- Increased intracranial pressure
- Circulatory failure or shock
- Avanafil
- Bromocriptine
- Cabergoline
- Dihydroergotamine
- Dihydroergotamine intranasal
- Ergoloid mesylates
- Ergotamine
- Methylergonovine
- Riociguat
- Sildenafil
- Tadalafil
- Vardenafil
Drug Status
| Availability | Prescription only |
| Pregnancy | Use with caution |
| Breastfeeding | Use with caution |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| GTN Spray | 400mcg/dose | Spray | 200D | Medley Pharma | Zawadi Healthcare |