Felodipine/ Metoprolol

Tablet:

• 5mg/10mg

• None remarkable

Felodipine: Dihydropyridine calcium blocker. It acts by reducing peripheral vascular resistance, especially in arterioles. It has a selective effect on smooth muscle in the arterioles. It also relaxes smooth muscle in the respiratory tract.

Metoprolol: Cardioselective beta-blocker. It maintains or improves left ventricular function in healthy subjects and in patients with hypertension by decreasing heart rate, increasing cardiac output and stroke volume. In also protects health by reducing oxidative stress and increasing nitric oxide bioavailability through non-receptor dependent scavenging of O2- and β,3-adrenergic receptor-dependent inhibition of NADPH oxidase and endothelial nitric oxide synthase uncoupling.

• Headache
• Peripheral edema
• Flushing
• Bradycardia
• Postural disorders
• Peripheral coldness of extremities
• Palpitations
• Dizziness
• Fatigue
• Constipation
• Diarrhoea

• Hypersensitivity to drug or ingredient
• Pregnancy
• Unstable angina pectoris
• 2° and 3° AV block
• Unstable uncompensated heart failure (pulmonary edema, hypoperfusion or hypotension)
• Continuous or intermittent inotropic therapy with β-receptor agonism
• Symptomatic bradycardia or hypotension
• Sick sinus syndrome
• Cardiogenic shock
• Severe peripheral vascular disease with threat of gangrene
• Obstructive cardiomyopathy

• Carbamazepine
• Phenytoin
• Phenobarbital
• Erythromycin
• Grapefruit juice