• Rheumatoid Arthritis (RA) – adults, with or without methotrexate
  • Psoriatic Arthritis (PsA)
  • Ankylosing Spondylitis (AS)

Dose:50 mg SC once weekly (or 25 mg SC twice weekly, 3–4 days apart)

  • Plaque Psoriasis – moderate to severe, adults & children ≥4 years

Dose: Plaque Psoriasis (≥4 years):0.8 mg/kg weekly (max 50 mg/week)

  • Polyarticular Juvenile Idiopathic Arthritis (JIA) – ages ≥2 years

Dose: JIA (≥2 years):0.8 mg/kg once weekly (max 50 mg/week)

  • Prefilled Syringes / Auto-injectors:
    • 25 mg/0.5 mL, 50 mg/mL
  • Lyophilized Powder for Reconstitution:
    • 25 mg per vial
  • Subcutaneous injection only (abdomen, thigh, upper arm)
  • Rotate injection sites
  • Refrigerate; allow to reach room temp before injection
  • Do not shake
  • Do not use if cloudy or discolored
  • Class: TNF-α inhibitor (fusion protein)
  • Mechanism of Action:
    • Soluble receptor fusion protein: binds TNF-α, preventing interaction with receptors
    • ↓ inflammatory cytokines, immune cell activation
  • Half-life: ~3–5 days
  • Peak levels: 48–60 hours post-injection
  • Excretion: Unknown; not cleared by kidneys
  • Injection site reactions (pain, redness, itching)
  • Infections (URIs, sinusitis)
  • Headache
  • Nausea
  • Rash
  • Sepsis or risk of life-threatening infections
  • Known hypersensitivity to etanercept or components
  • Avoid live vaccines during and after treatment
  • Do not combine with other biologics (e.g., infliximab, adalimumab)
  • May be used with methotrexate
  • Additive immunosuppressive effect with cyclosporine, corticosteroids

                                   Drug Status

Availability
Pregnancy
Breastfeeding
Schedule
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Enbrel 25mg Pre-Filled Syringe 1’s Pfizer Labs Pfizer Labs
Enbrel 50mg Pre-Filled Syringe 1’s Pfizer Labs Pfizer Labs