Esomeprazole/ Itopride

• Tablet/capsule:
  • 40mg/150mg
  • 20mg/150mg

• Taken 1 hour before meals, preferably in the morning

Esomeprazole: Proton pump inhibitor. It suppresses gastric acid secretion by specific inhibition of the H⁺/K⁺ ATPase enzyme system at the secretory surface of gastric parietal cells. It inhibits the proton pump, the final step in gastric acid secretion

Itopride: Prokinetic. It increases the level of acetylcholine concentration, increasing the peristalsis movement, thereby accelerating gastric emptying time and easing the movement of food through the entire GI tract. It also stops the sensation of vomiting/nausea by blocking the D2 receptors located in the chemoreceptor trigger zone.

• Stomach pain
• Diarrhea
• Headache
• Flatulence
• Increased saliva production

• GI bleeding
• Mechanical obstruction or perforation
• Clostridium difficile-associated diarrhoea (CDAD)
• Liver disease
• Bone fractures
• Hypomagnesemia

• Aspirin
• Naproxen
• Duloxetine
• Citalopram
• Diazepam
• Levothyroxine sodium
• Clopidogrel
• Cyanocobalamin (Vit B12)