Cilnidipine/ Nebivolol

• Tablet:
  • 10mg/5mg

• Can be taken with or without food

Cilnidipine: Dihydropyridine. It inhibits the influx of calcium ions into both vascular smooth muscle and cardiac muscle. The contraction of cardiac muscle and vascular smooth muscle are dependent on the movement of extracellular calcium ions into these cells by specific ion channels.

Nebivolol: Cardioselective beta-blocker. It maintains or improves left ventricular function in healthy subjects and in patients with hypertension by decreasing heart rate, increasing cardiac output and stroke volume. In also protects health by reducing oxidative stress and increasing nitric oxide bioavailability through non-receptor dependent scavenging of O2- and β,3-adrenergic receptor-dependent inhibition of NADPH oxidase and endothelial nitric oxide synthase uncoupling.

• Headache
• Slow heart rate
• Constipation
• Cold extremities
• Nausea
• Sleepiness
• Tiredness
• Palpitations
• Ankle swelling
• Flushing

• Hypersensitivity to components
• Diabetes
• Irregular heartbeat
• Low blood pressure
• Allergy

• Phenytoin
• Rifampicin
• Erythromycin
• Quinidine