• Complicated intra-abdominal infections:
    • Adults:
      • IV 2.5g TDS *5-14 days
      • Give with metronidazole PO/IV 500mg TDS/QID
    • 3-5 months old:
      • IV 50mg/kg/dose TDS* 5-14 days
      • Give with metronidazole 30 mg/kg/day IV divided TDS/QID
    • 6 months-1 year:
      • IV 62.5mg/kg/dose TDS *5-14 days
      • Give with metronidazole 30 mg/kg/day IV divided TDS/QID
    • ≥2 years:
      • IV 62.5mg/kg/dose TDS *5-14 days
      • Max: 2.5g/dose
  • Complicated UTI:
    • Adults:
      • IV 2.5g TDS *7-14 days
    • 3-5 months old:
      • IV 50 mg/kg/dose TDS *7-14 days
    • 6 months-1 year:
      • IV 62.5mg/kg/dose TDS *7-14 days
    • ≥2 years:
      • IV 62.5mg/kg/dose TDS *7-14 days
      • Max: 2.5g/dose
  • Hospital-acquired or ventilator-associated pneumonia:
    • Adults:
      • IV 2.5g TDS *1/52
    • 3-5 months old:
      • IV 50 mg/kg/dose TDS *7-14 days
    • 6 months-1 year:
      • IV 62.5mg/kg/dose TDS *7-14 days
    • ≥2 years:
      • IV 62.5mg/kg/dose TDS *7-14 days
      • Max: 2.5g/dose
  • Injection:
    • 2g/500mg
  • Infuse IV over 2 hours
  • Upon reconstitution, solution may be held for no longer than 30 minutes before transferring and further diluting in a suitable infusion bag

Ceftazidime: 3rd generation cephalosporin with broad-spectrum gram-negative activity. Inhibits cell-wall synthesis by binding to 1 or more penicillin-binding proteins thus bactericidal.

Avibactam: An irreversible inhibitor by covalently binding to β-lactamases, and prevents the enzyme hydrolysis of beta lactams

  • Diarrhea
  • Nausea
  • Vomiting
  • Rash (peds patients)
  • Infusion site reaction (peds patients)
  • Headache
  • Constipation
  • Dizziness
  • Abdominal pain
  • Pruritus
  • Hypersensitivity to class or components
  • None restricted

                                   Drug Status

Availability Prescription only
Pregnancy Can be used
Breastfeeding Can be used
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Zavicefta 2g/0.5g Injection 10’s Pfizer Labs Pfizer Labs