- Respiratory tract infections
- Urinary tract infections (upper and lower)
- Intra-abdominal infections
- Septicemia
- Meningitis
- Skin and soft tissue infections
- Bone and joint infections
- Endometritis a
- Other infections of the genital tract
Dose:
Adults: IV/IM 2-4g (i.e. 1-2g per day cefoperazone) divided BD
Children: IV/IM 40-80mg/kg/day (i.e. 20-40mg/kg/day cefoperazone) in 2 to 4 equally divided doses.
- Injection:
- 500mg/500mg
- 1g/1g
- None remarkable
Cefoperazone: 3rd generation cephalosporin with broad-spectrum gram-negative activity. Inhibits cell-wall synthesis by binding to 1 or more penicillin-binding proteins thus bactericidal.
Sulbactam: An irreversible inhibitor by covalently binding to β-lactamases, and prevents the enzyme hydrolysis of beta lactams
- Neutropenia
- Leukopenia
- Coombs direct test positive
- Haemoglobin decreased
- Haematocrit decreased
- Thrombocytopenia
- Hypersensitivity to class or components
- Anticoagulants
- Alcohol
Drug Status
| Availability | Prescription only |
| Pregnancy | Category B; weigh risk vs benefit |
| Breastfeeding | Weigh risk vs benefit |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Alemctum | 500mg/500mg | Injection | 1’s | Alembic Pharma | Europa Healthcare |
| Bactacef | 1g/1g | Injection | 1’s | Synermed Pharma | Synermed Pharma |
| Cefocel | 500mg/500mg | Injection | 1’s | Zawadi Healthcare | Zawadi Healthcare |
| Fytobact | 1g/1g | Injection | 1’s | Cadila Pharma | Cadila Pharm |