• Prophylaxis of respiratory distress syndrome in premature infants:
    • Intratracheally 4mL/kg/dose no more frequently than every 6hrs
      • Start ASAP within 15min of birth
      • Max 4 doses within 1st 48hrs of life
      • For patients with birth weight <1.25kg or evidence of surfactant deficiency, divide dose into 4 aliquots and administer in different positions
  • Rescue treatment in respiratory distress syndrome in premature infants:
    • Intratracheally 4mL/kg/dose no more frequently than every 6hrs
      • Start ASAP after ventilation and within 8h of life
      • Max: 4 doses within 1st 48hrs of life
      • Divide dose into 4 aliquots and administer in different positions
  • Injection:
    • 25mg/mL
  • Instill through 5 French endhole catheter inserted into endotracheal tube just above carina (not into bronchus)
  • Inject each dose into catheter over 2-3 seconds.
  • Each dose instilled as 4 quarter-doses, with body in different positions to assure adequate distribution
  • Allow 30 seconds ventilation between positions
  • Store in fridge, warm to room temp, swirl to mix (no shaking!)

Bovine lung surfactant

It prevents the alveoli from collapsing during expiration by lowering surface tension between alveolar surfaces and air

  • Bradycardia
  • Hypoxia
  • Hypersensitivity to components
  • None remarkable

                                   Drug Status

Availability Prescription only
Pregnancy Not applicable
Breastfeeding Not applicable
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Survanta Sterile Dispersion 25mg/mL Sterile Concentrate 4mL, 8mL Abbvie Phillips Therapeutics