Atenolol/ Nifedipine

• Tablet:
  • 50mg/20mg

• None remarkable

Atenolol: Cardioselective beta-1-adrenergic blocker. It competitively inhibit the action of adrenaline and noradrenaline on β1 receptors (the predominant β receptors in the heart), resulting in suppression of the sympathetic nervous system with negative inotropy, chronotropy, dromotropy and lusiotropy.

Nifedipine: Calcium channel blocker. It inhibits transmembrane influx of extracellular calcium ions across myocardial and vascular smooth muscle cell membranes without changing serum calcium concentrations; this results in inhibition of cardiac and vascular smooth muscle contraction, thereby dilating main coronary and systemic arteries. Vasodilation with decreased peripheral resistance and increased heart rate

• Headache
• Dizziness
• Fatigue
• Flushing
• GI upsets
• Impotence
• Oedema
• Purpura

• History of wheezing, asthma, obstructive respiratory disease
• Pronounced bradycardia (resting heart rate <50 beats/min prior to treatment)
• 2nd or 3rd degree heart block
• Sick sinus syndrome
• SA block
• Systolic pressure <90 mmHg
• Overt or decompensated cardiac failure (NYHA grades III & IV)
• Aortic stenosis
• Unstable angina
• Acute attacks of angina
• Acute MI or within 1 month of MI, or for secondary prevention of MI
• Cardiogenic shock
• Severe peripheral arterial circulatory disorders
• Acidosis
• Severe renal impairment
• Untreated phaeochromocytoma
• Malignant hypertension
• Lactation
• Pregnancy
• Women of child-bearing age

• Clonidine
• Grapefruit juice
• Diltiazem
• Verapamil
• Adrenaline
• Noradrenaline