Artenolane/ Piperaquine

• Arterolane maleate: Equivalent to 150 mg of arterolane base
• Piperaquine phosphate: Equivalent to 750 mg of piperaquine base
• (Note: Pediatric tablets may be lower in strength)

• Take once daily for 3 consecutive days
• Take with water and preferably after food to improve absorption
• Do not skip doses; complete the full treatment course
• Avoid taking with other medications that affect heart rhythm

Arterolane:

• A synthetic trioxolane with fast parasite-killing action (similar to artemisinin)
• Produces reactive oxygen species that damage parasite proteins
• Rapid reduction of parasitemia

Piperaquine:

• A long-acting antimalarial from the 4-aminoquinoline group
• Inhibits heme detoxification, leading to parasite death
• Maintains therapeutic levels after arterolane is cleared to prevent recurrence

Combination effect:

• Arterolane clears parasites quickly
• Piperaquine provides post-treatment prophylaxis and prevents recrudescence

Common:

• Headache
• Dizziness
• Nausea, vomiting
• Abdominal pain
• Weakness (asthenia)

Serious (rare):

• QT interval prolongation (risk of cardiac arrhythmias)
• Allergic reactions
• Hepatotoxicity

• Known hypersensitivity to arterolane or piperaquine
• Congenital QT prolongation or history of cardiac arrhythmia
• Severe hepatic or renal impairment
• Concurrent use of QT-prolonging medications

• QT-prolonging drugs (e.g., macrolides, quinolones, antipsychotics): May increase risk of cardiac arrhythmias.
• CYP3A4 inhibitors/inducers: May alter piperaquine levels.
• Antimalarial drugs or other hepatotoxic agents: Increased risk of adverse effects.