Amlodipine/ Metoprolol

Tablet:

• 5mg/25mg
• 5mg/50mg

• Drink plenty of fluids while taking this medicine to overcome muscle weakness, dry mouth and extreme thirst

Amlodipine: Dihydropyridine calcium channel blocker. It inhibits the influx of calcium ions into both vascular smooth muscle and cardiac muscle. The contraction of cardiac muscle and vascular smooth muscle are dependent on the movement of extracellular calcium ions into these cells by specific ion channels. It is also considered a peripheral arterial vasodilator that exerts its action directly on vascular smooth muscle to lead to a reduction in peripheral vascular resistance, causing a decrease in blood pressure.

Metoprolol: Cardioselective beta-blocker. It maintains or improves left ventricular function in healthy subjects and in patients with hypertension by decreasing heart rate, increasing cardiac output and stroke volume. In also protects health by reducing oxidative stress and increasing nitric oxide bioavailability through non-receptor dependent scavenging of O2- and β,3-adrenergic receptor-dependent inhibition of NADPH oxidase and endothelial nitric oxide synthase uncoupling.

• Oedema
• Dizziness
• Flushing
• Palpitation
• Vertigo
• Bradycardia
• Headache
• Feeling exhausted
• Swollen ankles
• Flushing
• Stomach upset
• Increased levels of potassium in the blood
• Dry mouth
• Change in taste
• Blurred vision
• Difficulty in breathing
• Cold fingers or toes

• Hypersensitivity to drug or ingredient
• Diabetes
• Asthma
• Cardiogenic shock
• Heart valve problem
• Hypotension
• Coronary heart disease
• Liver disease
• Heart failure

• Digitalis
• Clonidine
• Calcium Channel Blockers e.g. diltiazem and verapamil
• Quinidine
• Fluoxetine
• Paroxetine
• Propafenone