• Parkinsonism disease:
    • Initially PO 0.125mg TDS*1/52, then 0.25mg TDS*1/52, then may increase by 0.75mg/day *1/52
    • Max: 4.5mg/day
    • Taper dose by 0.75mg/day to 0.25mg TDS, then taper dose by 0.375mg/day to discontinue
  • Restless legs syndrome:
    • Initially PO 0.125mg nocte *4-7 days, then may increase to 0.25mg *4-7 days, then may increase to 0.5mg nocte
    • Max: 0.5mg/day
    • Given 2-3 hours before bedtime
  • Sleep-related eating disorder (Off-label):
    • PO 0.125mg nocte, then may titrate slowly
  • Rapid eye movement sleep behavior disorder (Off-label):
    • PO 0.125mg nocte, then may titrate slowly
  • Tablet:
    • 0.25mg
    • 1mg
    • 0.5mg

Taken without regards to meals

Non-ergot dopamine D2 receptor agonist

It stimulates dopamine receptors

  • Orthostatic hypotension
  • Dyskinesia
  • Somnolence
  • Nausea
  • Extrapyramidal symptoms
  • Insomnia
  • Dizziness
  • Hallucinations
  • Headache
  • Fatigue
  • Asthenia
  • Constipation
  • Rebound symptoms (RLS use)
  • Rls augmentation symptoms (RLS use)
  • Abnormal dreams
  • Confusion
  • Xerostomia
  • Diarrhea
  • Influenza
  • Amnesia
  • Urinary frequency
  • Peripheral edema
  • Muscle spasms
  • Anorexia
  • Dyspepsia
  • Vomiting
  • Visual disturbance
  • Malaise
  • Sudden sleep episodes
  • Abdominal pain
  • Increased appetite
  • Cough
  • Dysphagia
  • Weight loss
  • Impotence
  • Depression
  • Back pain
  • Compulsive behaviors
  • Skin reaction
  • Withdrawal symptoms
  • Hypersensitivity to components
  • Abrupt withdrawal

None restricted

                          Drug Status

Availability Prescription only
Pregnancy Category C
Breastfeeding Contraindicated
Schedule Controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Pexola 0.25mg Tablet 100’s Boehringer Ingelheim Surgipharm Ltd
Pexola 1mg Tablet 100’s Boehringer Ingelheim Surgipharm Ltd
Pexola 0.125mg Tablet 100’s Boehringer Ingelheim Surgipharm Ltd
Pramiplex 0.25mg Tablet 30’s Sun Pharma Sun Pharma
Pramiplex 0.5mg Tablet 30’s Sun Pharma Sun Pharma
Pramiplex 1mg Tablet 30’s Sun Pharma Sun Pharma
Ramipex 0.25mg Tablet 30’s Torrent Pharma C/O Medox Medox Pharma
Ramipex 1mg Tablet 30’s Torrent Pharma C/O Medox Medox Pharma