• Advanced prostrate cancer:
    • IM 7.5mg monthly OR
    • IM 22.5mg every 3 months OR
    • IM 30mg every 4 months OR
    • IM 45mg every 6 months
  • Injection:
    • 3.75mg
    • 11.25mg
  • Administer IM by inserting needle at a 900 angle into gluteal area, anterior thigh or shoulder
  • For SC, do NOT inject in areas with brawny or fibrous subcutaneous tissue or locations that can be rubbed or compressed (e.g. with a belt or clothing waistband)
  • Alternate injection sites

GNRH Agonist

It inhibits gonadotropin release, LH and FSH, suppressing ovarian and testicular steroidogenesis. Testosterone levels reduced to below castrated levels in males

  • Hot flashes
  • Diaphoresis
  • Transient tumor flare
  • Headache
  • Vaginitis (endometriosis or uterine fibroid use)
  • Depression
  • Emotional lability
  • Generalized pain
  • Joint disorder
  • Dyspepsia
  • Edema
  • Weight changes
  • Dizziness
  • Acne
  • Breast tenderness
  • Gynecomastia
  • Injection site reaction
  • Insomnia
  • Sexual dysfunction
  • Urogenital disorders
  • Paresthesia
  • Neuromuscular disorder
  • Asthenia
  • Hypersensitivity to components/class
  • Pregnancy
  • Undiagnosed vaginal bleeding (endometriosis or uterine fibroid use)
  • Amiodarone
  • Anagrelide
  • Arsenic trioxide
  • Artemether
  • Artemether/Lumefantrine
  • Citalopram
  • Disopyramide
  • Dofetilide
  • Dronedarone
  • Eliglustat
  • Escitalopram
  • Fluoxetine
  • Ibutilide
  • Iloperidone
  • Lopinavir
  • Lumefantrine
  • Mifepristone
  • Nilotinib
  • Paliperidone
  • Pimozide
  • Procainamide
  • Quetiapine
  • Quinidine
  • Sotalol
  • Tetrabenazine
  • Thioridazine
  • Toremifene
  • Vandetanib
  • Vemurafenib
  • Ziprasidone

                          Drug Status

Availability Prescription only
Pregnancy Contraindicated
Breastfeeding Not indicated
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Eurolide 3.75mg Injection 1’s Samarth Life Sciences Nairobi Enterprises
Lorelin 11.25mg Injection 1’s Dong Kook Pharma Proline Healthcare
Lupride Depot 3.75mg Injection 1’s Sun Pharma Sun Pharma
Lupride Depot 11.25mg Injection 1’s Sun Pharma Sun Pharma
Luprodex 3.75mg Injection 1’s Bharat Serum Nairobi Enterprises