• Reduce the risk of preterm birth:
    • IM 250mg every week until 37 week gestation or delivery
    • Initiate between the 16th and 20th week of gestation

Injection: 250mg/mL

  • Slow IM injection in upper outer quadrant of the gluteus maximus
  • Rotate injection site to alternate side from previous week

Synthetic progestin

Exact mechanism of action unknown

  • Injection site reaction
  • Urticaria
  • Premature labor
  • Pre-eclampsia
  • Pruritus
  • Nausea
  • Diabetes mellitus
  • Diarrhea
  • Fluid retention
  • Injection site cellulitis
  • Thromboembolism or history of thromboembolism
  • Breast cancer or history of breast cancer
  • Hormone sensitive cancer or history of hormone sensitive cancer
  • Undiagnosed abnormal vaginal bleeding unrelated to pregnancy
  • Cholestatic jaundice of pregnancy
  • Liver tumors or active liver disease
  • Uncontrolled hypertension
  • Hypersensitivity to castor oil or hydroxyprogesterone caproate

None restricted

                          Drug Status

Availability Prescription only
Pregnancy Indicated
Breastfeeding Not indicated
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Primolut Depot 250mg/mL Injection 1’s Bayer Schering Bayer Schering