• To decrease infection incidence in patients receiving myelosuppressive chemotherapy treatment associated with a significant incidence of severe febrile neutropenia:
    • SC/IV infusion 5mcg/kg/day until neutrophil count in normal range (about 14-38 days)
      • Started at least 24 hours after cytotoxic chemotherapy
      • Preferably given SC
      • If given IV, administer over 30 minutes
  • Reduction in duration of neutropenia (and associated sequelae) in myeloablative therapy followed by bone marrow transplantation:
    • SC/IV infusion 10mcg/kg/day over 4-24 hours (Max 24 hour infusion)
  • Peripheral blood progenitor cell collection by leukapheresis:
    • Monotherapy: SC/IV infusion 10mcg/kg daily *5-7 days
    • Following adjunctive chemotherapy: SC/IV infusion 5mcg/kg daily
      • To be administered over 24 hours if given SC
      • Started 4 days before 1st leukapheresis and continued through last leukapheresis
  • Severe chronic neutropenia:
    • Congenital: Initial SC 6mcg/kg BD
    • Idiopathic/cyclic: Initial SC 5 mcg/kg OD
  • Hematopoietic syndrome of acute radiation syndrome:
    • SC 10mcg/kg OD
  • Persistent neutropenia in HIV infection:
    • Initially SC 1mcg/kg OD
      • Dose increased according to neutrophil count
      • Max: 4mcg/day
  • Infusion/injection:
    • 6mg/0.6mL
    • 300mcg
  • Pre-filled syringe:
    • 30mcg
  • To be refrigerated
  • Discard any vial or prefilled syringe left at room temperature for >24 hours
  • Avoid shaking
  • Rotate injection site daily
  • Do not inject into an area that is tender, red, bruised or hard or that has scars or stretch marks

Recombinant human granulocyte-colony stimulating factor (G-CSF)

It works by binding to receptors on hematopoietic cells, increasing neutrophil production, activation and migration

  • Nausea
  • Thrombocytopenia
  • Fever
  • Fatigue
  • Bone pain
  • Back pain
  • Dizziness
  • Cough
  • Rash
  • Chest pain
  • Dyspnea
  • Hypersensitivity to class/components
  • Chemotherapy use within 24 hours
  • Radiotherapy within 24 hours

None restricted

                          Drug Status

Availability Prescription only
Pregnancy Unknown; Use with caution
Breastfeeding Use with caution
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Filgrastim 300mcg/mL Pre-Filled Syringe 1’s Cadila Healthcare Cadila Healthcare
Neutas 300mcg/mL Pre-Filled Syringe 1’s Intas Pharma Accord Healthcare
Religrast 300mcg/mL Pre-Filled Syringe 1’s Galaxy Pharma Galaxy Pharma