• Advanced breast cancer for postmenopausal patients who have failed letrozole or anastrozole:
    • 10mg OD
    • Given with exemestane
  • Progressive neuroendocrine tumors for patients with unresectable, locally advanced or metastatic tumors of pancreatic, GI or lung origin:
    • 10mg OD
  • Advanced renal cell carcinoma for patients who have failed sunitinib or sorafenib:
    • Monotherapy: 10mg OD
    • Combination with lenvatinib: 5mg OD
  • TSC-associated renal angiomyolipoma for patients not requiring immediate surgery:
    • 10mg OD
  • TSC-associated subependymal giant cell astrocytoma for patients who cannot be curatively resected:
    • 5mg/m2/day
    • May adjust dose by up to 5 mg/day every 1-2 weeks based on trough levels
  • TSC-associated partial onset seizures:
    • 5mg/m²/day
    • May adjust dose by up to 5 mg/day every 1-2 weeks based on trough levels
  • Tablet:
    • 5mg
    • 10mg

Administered consistently with food or consistently without food

mTOR Kinase Inhibitor

It inhibits mammalian target of rapamycin (mTOR) kinase activity, resulting in cell death by binding to the cellular cytoplasmic protein to form an immunosuppressive complex

  • Anemia
  • Hyperglycemia
  • Increased LFTs
  • Stomatitis
  • Hypercholesterolemia
  • Rash
  • Decreased serum bicarbonate
  • Diarrhea
  • Fatigue
  • Thrombocytopenia
  • Leukopenia
  • Electrolyte abnormalities
  • Edema
  • Hypertriglyceridemia
  • Abdominal pain
  • Nausea
  • Vomiting
  • Fever
  • Anorexia
  • Headache
  • Neutropenia
  • Weight loss
  • URI
  • Epistaxis
  • Nail disorder
  • Pruritus
  • Dyspnea
  • Asthenia
  • Dysgeusia
  • Pneumonitis
  • UTI
  • Cough
  • Arthralgia
  • Hypersensitivity to class/components
  • Hypersensitivity to sirolimus
  • Unhealed surgical wound
  • Avoid breastfeeding during treatment and for 2 weeks after discontinuation
  • Live bacterial vaccines
  • Cidofovir
  • Cisapride
  • Ritonavir
  • Tamoligene

                          Drug Status

Availability Prescription only
Pregnancy Category C
Breastfeeding Contraindicated
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Afinitor 5mg Tablet 30’s Novartis Pharma Novartis Kenya
Afinitor 10mg Tablet 30’s Novartis Pharma Novartis Kenya