- HIV infection:
- Adults:
- 600mg OD at bedtime
- >50kg in co-administration with rifampicin: 800mg OD at bedtime
- Adults:
-
- Children >3 months old:
- 3.5 kg to <5 kg: 100mg OD
- 5 to <7.5 kg: 150mg OD
- 7.5 to <15 kg: 200mg OD
- 15 to <20 kg: 250mg OD
- 20 to <25 kg: 300mg OD
- 25 to <32.5 kg: 350mg OD
- 32.5 to <40 kg: 400mg OD
- ≥40 kg: 600mg OD
- Children >3 months old:
- Tablet:
- 200mg
- 600mg
Taken on an empty stomach
Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs)
It inhibits reverse transcriptase and incorporates into viral DNA thereby causing DNA chain termination
- Rash
- Dizziness
- Depression
- Insomnia
- Anxiety
- Impaired concentration
- Nausea & vomiting
- Hyperlipidemia
- Somnolence
- Nervousness
- Headache
- Fatigue
- Decreased neutrophils
- Abnormal dreams
- Elevated ALT/AST
- Diarrhea
- Dyspepsia
- Hyperamylasemia
- Hyperglycemia
- Abdominal pain
- Pain
- Pruritus
- Anorexia
- Lipodystrophy
- Hypersensitivity to components
- Breastfeeding
- Not recommended for women of child-bearing potential
- Carbamazepine
- Cariprazine
- Cobimetinib
- Dienogest/estradiol valerate
- Doravirine
- Dronedarone
- Elbasvir/grazoprevir
- Elvitegravir/cobicistat/emtricitabine/tenofovir ergonovine
- Etravirine
- Fostemsavir
- Isavuconazonium sulfate
- Lefamulin
- Lomitapide
- Lonafarnib
- Lorlatinib
- Lumacaftor/ivacaftor
- Mavacamten
- Nevirapine
- Ombitasvir/paritaprevir/ritonavir
- Ombitasvir/paritaprevir/ritonavir & dasabuvir
- Panobinostat
- Posaconazole
- Praziquantel
- Ranolazine
- Rilpivirine
- Voriconazole
Drug Status
| Availability | Prescription only |
| Pregnancy | Category D |
| Breastfeeding | B/feeding contraindicated |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Efariv | 200mg | Tablet | 90’s | Cosmos Ltd | Cosmos Ltd |
| Efariv | 600mg | Tablet | 30’s | Cosmos Ltd | Cosmos Ltd |
| Efavir | 600mg | Tablet | 30’s | Cipla Ltd | Phillips |
| Efavirenz | 600mg | Tablet | 30’s | Aurobindo Pharma | Simba Pharma |
| Efavirenz | 600 mg | Tablet | 30’s | Mylan Labs C/O Surgilinks Ltd | Surgilinks Ltd |
| Efavirenz | 200mg | Tablet | 90’s | Strides Pharma Science | Universal Corporation |
| Efavirenz | 600mg | Tablet | 30’s | Strides Pharma Science | Universal Corporation |
| Stocrin | 600mg | Tablet | 30’s | MSD Ltd | Imperial Managed |