• Breast cancer:
    • Node-positive adjuvant treatment:
      • IV 75mg/m² 1 hour after doxorubicin and cyclophosphamide every 3 weeks x 6 cycles
    • Monotherapy in locally advanced or metastatic cancer:
      • IV 60-100mg/m² over 1 hour every 3 weeks
    • Metastatic disease, combined with capecitabine:
      • IV 75mg/m²/dose**1 every 3 weeks
      • For anthracycline-resistant disease
  • Locally advanced or metastatic non-small cell lung cancer:
    • IV 75mg/m2 over 1 hour every 3 weeks
  • Hormone-refractory metastatic prostate cancer(castration resistant) in combination with prednisone:
    • IV 75mg/m2 over 1 hour every 3 weeks with daily prednisone PO 5mg BD
    • Up to 10 cycles
  • Advanced gastric cancer in patients who have not received prior chemotherapy for advanced disease:
    • Day 1: 75mg/m2 IV infusion over 1 hour then cisplatin 75mg/m2 as a 1-3 hr infusion
    • Post cisplatin: Fluorouracil 750mg/m2 OD given as a 24-hr continuous infusion *5/7
    • Repeat every 3 weeks
  • Locally advanced squamous cell head/neck carcinoma:
    • Day 1: 75mg/m2 IV infusion over 1 hour then cisplatin 75-100mg/m2 as a 1-3 hr infusion
    • Post cisplatin: Fluorouracil 750mg/m2 OD given as a 24-hr continuous infusion *5/7
    • Repeat every 3 weeks for 3-4 cycles

Injection:

  • 20mg/mL
  • 20mg/0.5mL
  • 80mg/2mL
  • 120mg/3mL
  • To be used within 4 hours of dilution
  • Non-PVC tubing used
  • When administered as sequential infusions, taxane derivatives should be administered before platinum derivatives (cisplatin, carboplatin) to decrease risk of myelosuppression and to enhance efficacy
  • Pre-medicate with dexamethasone

Taxane anticancer

It promotes formation and inhibits disassembly of stable microtubules thereby inhibiting mitosis

  • Neutropenia
  • Leukopenia
  • Anemia
  • Alopecia
  • Asthenia
  • Fluid retention
  • Fatigue
  • Nausea
  • Diarrhea
  • Sensory neuropathy
  • Infection
  • Nail changes
  • Stomatitis
  • Pharyngitis
  • Taste changes
  • Hyperbilirubinemia
  • Elevated ALT/AST
  • Vomiting
  • Anorexia
  • Dyspnea
  • Arthralgia
  • Myalgia
  • Cough
  • Lacrimation
  • Rash
  • Desquamation
  • Hypersensitivity reaction
  • Thrombocytopenia
  • Constipation
  • Pain
  • Amenorrhea
  • Hypersensitivity to class/components
  • Hypersensitivity to polysorbate 80
  • 1st trimester pregnancy
  • Avoid breastfeeding during treatment and for 1 week after discontinuing
  • ANC <1500
  • Platelet count <100,000
  • Bilirubin elevated
  • ALT or AST >1.5x ULN with alk phos >2.5x ULN

WARNING:

  • Increased mortality reported in patients with liver impairment
  • Severe neutropenia with infection may occur
  • Severe hypersensitivity reaction
  • Severe fluid retention
  • Use effective contraception during treatment and for 6 months after discontinuing in female patients and during treatment and for 3 months after discontinuing in male patients
  • Live vaccines
  • Disulfiram
  • Metronidazole
  • Topiramate
  • Talimogene

                          Drug Status

Availability Prescription only
Pregnancy Category D
Breastfeeding Contraindicated
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Adoxi 20mg/0.5mL Injection 1’s M/S Beta Drugs Galaxy Pharma
Adoxi 80mg/2mL Injection 1’s M/S Beta Drugs Galaxy Pharma
Adoxi 120mg/3mL Injection 1’s M/S Beta Drugs Galaxy Pharma
Celtere 120mg/3mL Injection 1’s Celon Labs Europa Healthcare
D-tail 80mg Injection 1’s PSM Pharma PSM Pharma
D-tail 120mg Injection 1’s PSM Pharma PSM Pharma
Docecord 20mg/mL Injection 4mL Intas Pharma Accord Healthcare
Docetax 80mg/2mL Injection 1’s Cipla Ltd Imperial Managed
Docetax 20mg/0.5mL Injection 1’s Cipla Ltd Imperial Managed
Docetec 80mg/2mL Injection 1’s United Biotech Salama Pharma
Docetec 20mg/0.5mL Injection 1’s United Biotech Salama Pharma
Doxol 20mg/0.5mL Injection 1’s Venus Remedies Surgipharm Ltd
Doxol 80mg/2mL Injection 1’s Venus Remedies Surgipharm Ltd
Doxol 120mg/3mL Injection 1’s Venus Remedies Surgipharm Ltd
Taceedo 20mg/0.5mL Injection 1’s Miracalus Ripple Pharma
Taceedo 80mg/2mL Injection 1’s Miracalus Ripple Pharma
Taceedo 120mg/3mL Injection 1’s Miracalus Ripple Pharma
Taxotere 20mg/2mL Injection 1’s Sanofi-Aventis Ressourcethica Kenya
Taxotere 80mg/4mL Injection 1’s Sanofi-Aventis Ressourcethica Kenya
Taxuba 80mg/2mL Injection 1’s Glenmark Pharma Glenmark Pharma
Taxuba 20mg/0.5mL Injection 1’s Glenmark Pharma Glenmark Pharma
Taxwell 20mg/0.5mL Injection 1’s Getwell Pharma Nairobi Enterprises
Taxwell 80mg/2mL Injection 1’s Getwell Pharma Nairobi Enterprises
Taxwell 160mg/4mL Injection 1’s Getwell Pharma Nairobi Enterprises