- HIV infection:
- Treatment-naïve patients:
- 800mg + ritonavir 100mg OD OR cobicistat 150mg OD
- Treatment-naïve patients:
-
- Treatment-experienced without DRV resistance:
- 800mg OD + ritonavir 100mg BD
- 800mg OD + ritonavir 100mg BD
- Treatment-experienced without DRV resistance:
-
- Treatment-experienced with DRV resistance:
- 600mg BD + ritonavir 100mg BD
- 600mg BD + ritonavir 100mg BD
- Treatment-experienced with DRV resistance:
-
- Pregnant females:
- 600mg BD + ritonavir 100mg BD
- Consider 800mg OD + ritonavir 100mg in virally suppressed patients stable on regimen before pregnancy if compliance or tolerability concerns
- Pregnant females:
Tablet:
- 75mg
- 150mg
- 400mg
- 600mg
- 800mg
- Taken whole with food
Protease inhibitor
It binds to the active site of HIV protease, preventing mature virus particle formation
- Diarrhea
- Nausea & vomiting
- Headache
- Rash
- Hypercholesterolemia
- Hypertriglyceridemia
- Hyperamylasemia
- Hyperlipasemia
- Elevated ALT/AST
- Hyperglycemia
- Diabetes mellitus
- Abdominal pain
- Asthenia
- Anorexia
- Lipodystrophy
- Hypersensitivity to class/components
- Pregnancy (concomitant cobicistat use)
- Patients <3 years
- Alfuzosin
- Butabarbital
- Butalbital
- Carbamazepine
- Cisapride
- Colchicine
- Dihydroergotamine
- Dronedarone
- Elbasvir
- Ergotamine
- Flibanserin
- Fosphenytoin
- Grazoprevir
- Ivabradine
- Lomitapide
- Lonafarnib
- Lovastatin
- Lurasidone
- Methylergonovine
- Midazolam
- Naloxegol
- Pentobarbital
- Phenobarbital
- Phenytoin
- Pimozide
- Primidone
- Ranolazine
- Rifampin
- Sildenafil
- Simvastatin
- Thioridazine
- Tolvaptan
- Triazolam
Drug Status
| Availability | Prescription only |
| Pregnancy | Can be used |
| Breastfeeding | B/feeding contraindicated |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Darunavir | 600mg | Tablet | 60’s | Hetero Labs | Unisel Ltd |
| Darunavir | 600mg | Tablet | 60’s | Laurus Labs | Medisel Kenya |
| Darunavir | 800mg | Tablet | 30’s | Laurus Labs | Medisel Kenya |
| Prezista | 75mg | Tablet | 480’s | Janssen-Cilag | Phillips Therapeutics |
| Prezista | 150mg | Tablet | 240’s | Janssen-Cilag | Phillips Therapeutics |
| Prezista | 400mg | Tablet | 60’s | Janssen-Cilag | Phillips Therapeutics |
| Prezista | 600mg | Tablet | 60’s | Janssen-Cilag | Phillips Therapeutics |