- Type II DM:
- 1-2 tabs AM
- Max: 10mg/2000mg per day
- 10mg dapagliflozin when initiated due to HF/CKF
Tablet:
- 5mg/1g
- 5mg/850mg
- 5mg/500mg
- 10mg/1g
To be administered in the morning with food
Dapagliflozin: (SGLT2) inhibitor
Metformin: Biguanide
- Genital mycotic infection
- Vitamin B12 deficiency
- Nasopharyngitis
- UTI
- Diarrhea
- Headache
- Influenza
- Nausea & vomiting
- Back pain
- Dizziness
- Cough
- Constipation
- Dyslipidemia
- Pharyngitis
- Increased urination
- Urinary discomfort
- Increased creatine
- Orthostatic hypotension
- Metallic taste
- Rash
- Ovulation induction
- Hypersensitivity to class/components
- Pregnancy 2nd or 3rd trimester
- eGFR <30
- eGFR 30-45 (treatment initiation use)
- Dialysis
- Type I DM
- Metabolic acidosis
- Diabetic ketoacidosis
- Lactic acidosis
- Hypoxemia
- Volume depletion
- Dehydration
- Sepsis
- Surgery
- Hepatic disease
WARNING:
Post-marketing cases of hypothermia, hypotension, resistant bradyarrhythmias and death reported. If suspected, discontinue drug and immediately hospitalize the patient
None restricted
Drug Status
| Availability | Prescription only |
| Pregnancy | Category C |
| Breastfeeding | Contraindicated |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Dapaflo M | 5mg/500mg | Tablet | 30’s | Dawa Ltd | Dawa Ltd |
| Dapaflo M | 5mg/1g | Tablet | 30’s | Dawa Ltd | Dawa Ltd |
| Dapamet XR | 10mg/1g | Tablet | 30’s | Innocia Lifesciences | Wessex Pharma |
| Dapamet XR | 5mg/1g | Tablet | 30’s | Innocia Lifesciences | Wessex Pharma |
| Dapaveldactin Plus | 5mg/850mg | Tablet | 28’s | Liptis Pharma | Goodman Agencies |
| Dapaveldactin Plus | 5mg/1g | Tablet | 28’s | Liptis Pharma | Goodman Agencies |
| Dapazin M | 5mg/500mg | Tablet | 14’s | Zawadi Healthcare | Zawadi Healthcare |
| Dapazin M | 10mg/1g | Tablet | 14’s | Zawadi Healthcare | Zawadi Healthcare |
| Dapazin M | 5mg/1g | Tablet | 14’s | Zawadi Healthcare | Zawadi Healthcare |
| Dapiga 10M | 10mg/1g | Tablet | 30’s | Zawadi Healthcare | Zawadi Healthcare |
| Dapiga 5M | 5mg/500mg | Tablet | 30’s | Zawadi Healthcare | Zawadi Healthcare |
| Dapiga 5MF | 5mg/1g | Tablet | 30’s | Zawadi Healthcare | Zawadi Healthcare |
| Xiga-Met | 5mg/1g | Tablet | 14’s | CCL Pharma | Harley’s Ltd |
| Xiga-Met | 5mg/850mg | Tablet | 14’s | CCL Pharma | Harley’s Ltd |