• Type II DM:
    • Middle-aged stable patient: PO 250mg OD
    • Older patients: PO 100-125mg OD
      • May increase/decrease PRN by 50-125 mg/day at 3-5 day intervals
      • Max 750mg/day

Tablet: 250mg

Taken 30 min before meals

Sulfonylurea

It increases beta-cell insulin secretion. It may also decrease rate of hepatic glucose production, increase insulin receptor sensitivity and increases number of insulin receptors.

  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
  • Facial flushing after taking alcohol
  • Hypoglycemia
  • Headache
  • Dizziness
  • Hypersensitivity to drug/class
  • Hypersensitivity to sulphur
  • Insulin-dependent diabetes
  • Ketoacidosis
  • Severe infection
  • Severe renal or hepatic dysfunction
  • Dronabiol
  • Thiazides decrease effect

                          Drug Status

Availability Prescription only
Pregnancy Category C
Breastfeeding Not recommended
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Dibonis 250mg Tablet 28’s, 112’s Cosmos Ltd Cosmos Ltd