- Candidemia including intra-abdominal abscess, peritonitis, pleural space infections:
- Day 1 LD: IV 70mg *1 infused over 1 hour
- Maintenance: IV 50mg OD infused over 1 hour
- Continue for 14 days after last positive culture
- Esophageal candidiasis:
- Day 1 LD: IV 70mg *1 infused over 1 hour
- Maintenance: IV 50mg OD infused over 1 hour
- Continue for 7-14 days after symptoms resolve
- Febrile neutropenia:
- Day 1 LD: IV 70mg *1 infused over 1 hour
- Maintenance: IV 50mg OD infused over 1 hour
- May be increased to a max of 70mg/day
- Continue until resolution of neutropenia or if fungal infection found, continue for a minimum of 14 days or for 7 days after resolution of neutropenia and clinical symptoms
- Refractory aspergillosis in patients intolerant of other therapies (e.g, amphotericin B, itraconazole):
- Day 1 LD: IV 70mg x1 infused over 1 hour
- Maintenance: IV 50mg OD infused over 1 hour
- May be increased to a max of 70mg/day
Injection:
- 50mg
- 70mg
- Use reconstituted infusion solution within 24 hours if stored at room temp or within 48 hour if refrigerated at 2-8°C
Echinocandin antifungal
It inhibits synthesis of 1,3-beta-D-glucan thereby inhibiting fungal cell wall synthesis
- Fever
- Infusion reaction
- Diarrhea
- Elevated ALT/AST
- Hypokalemia
- Phlebitis
- Rigors
- Headache
- Respiratory distress
- Nausea
- Septic shock
- Hypotension
- Pleural effusion
- Hypersensitivity to class/compound
- Cyclosporine
Drug Status
| Availability | Prescription only |
| Pregnancy | Contraindicated |
| Breastfeeding | Contraindicated |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Cancidas | 50mg | Injection | 1’s | MSD Ltd | Imperial Managed |
| Cancidas | 70mg | Injection | 1’s | MSD Ltd | Imperial Managed |
| Casdin | 50mg | Injection | 1’s | Gufic Stridden Biopharma | Europa Healthcare |
| Casdin | 70mg | Injection | 1’s | Gufic Stridden Biopharma | Europa Healthcare |