• Bradycardia in ACLS:
    • IV 0.5-1mg every 3-5min PRN
  • Anesthesia adjunct:
    • SC/IM/IV 0.5-1mg every 4-6hours PRN
    • Max: 3 mg/total dose
    • Info: give 1st dose 30-60min pre-op
    • 03-0.04mg/kg/max total dose for patients with CAD
  • Neuromuscular blockade reversal adjunct:
    • IV 0.6-1.2mg for each 0.5-2.5mg neostigmine or 10-20mg pyridostigmine dose
  • Organophosphate nerve agent poisoning:
    • Adults: Initially IM 2-4mg x1 for mild/moderate symptoms; IM 6mg x1 for severe symptoms
      • Continue atropinization until muscarinic symptoms gone
      • For frail/elderly patients start IM 1mg *1 for mild/moderate symptoms, IM 2-4 mg *1 for severe symptoms
    • <2 years old: IM 0.05mg/kg/dose every 5-10min PRN
      • IM 0.1mg/kg/dose for severe symptoms
    • 2-10 year old: IM 1mg every 5-10min PRN
      • IM 2mg *1 for severe symptoms
    • >10 year old: IM 2mg every 5-10min PRN
      • IM 4mg *1 for severe symptoms
  • Organophosphate or carbamate insecticide poisoning:
    • Adults: IV 1-3mg x1, then may double dose every 3-5min PRN
      • May give 10-20% loading dose/hour IV infusion once patient is stabilized
      • Continue atropinization until muscarinic symptoms gone
    • Paeds: Initially IV 0.02mg/kg/dose x1, then may double dose every 3-5min PRN

Injection: 0.6mg/mL

Give into large vein or IV tubing over 1-2 min

It competitively inhibits action of acetylcholine on autonomic effectors innervated by postganglionic nerves. It reverses muscarinic effects of cholinergic poisoning caused by agents with cholinesterase inhibitor activity by acting as a competitive antagonist of acetylcholine at the muscarinic receptors.

It blocks action of acetylcholine at parasympathetic sites in secretory glands, and CNS. It inhibits salivation, tracheobronchial secretions, bradycardia and hypotension

  • Xerostomia
  • Blurred vision
  • Photophobia
  • Tachycardia
  • Constipation
  • Difficulty urinating
  • Xeroderma
  • Mydriasis
  • Confusion
  • Headache
  • Dizziness
  • Flushing
  • Urinary retention
  • Abdominal distension
  • Nausea & vomiting
  • Heat intolerance
  • Impaired body temperature regulation
  • Restlessness
  • Tremor
  • Fatigue
  • Injection site pain
  • Rash
  • Delirium
  • Impotence
  • Hypersensitivity to class/components
  • Potassium salts

                          Drug Status

Availability Prescription only
Pregnancy Use with caution
Breastfeeding Use with caution
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Atrop 1% w/v Eye Drops 5mL Dawa Ltd Dawa Ltd
Atropine 1% w/v Injection 10’s Dawa Ltd Dawa Ltd
Atropine 0.6mg/mL Injection 10’s Laborate India Harley’s Ltd
Atro 1mg/mL Injection 10’s Zawadi Healthcare Zawadi Healthcare
Atrop 1% w/v Eye Drops 5mL Aurolab Aurolab
Atropine Sulphate 0.1mg/mL Pre-filled Syringe 5mL*10’s Laboratoire Renaudin Nairobi Pharma
Atropine Sulphate 0.2mg/mL Pre-filled Syringe 5mL*10’s Laboratoire Renaudin Nairobi Pharma