- Uncomplicated malaria (20mg/120mg):
- Adults: 4 tabs BD *3/7
- 5-14 kg: 1 tab BD *3/7
- 15-24 kg: 2 tabs BD *3/7
- 25-34 kg: 3 tabs BD *3/7
Tablet:
- 20mg/120mg
- 80mg/480mg
- 60mg/360mg
- 40mg/240mg
Suspension:
- 180mg/1080mg per 60mL
- 15mg/90mg per 60mL
- 360mg/2160mg per 60mL
- Taken with food
- If patient vomits out dose within 1-2 hours, give another dose
Artemether and lumefantrine inhibit nucleic acid/protein synthesis during erythrocytic stages of P. falciparum
Artemether and metabolite dihydroartemisinin act via endoperoxide moiety
Lumefantrine binds heme inhibiting beta-hematin formation
- Headache
- Anorexia
- Dizziness
- Asthenia
- Arthralgia
- Myalgia
- Nausea
- Fever
- Rigors
- Sleep disorders
- Palpitations
- Vomiting
- Abdominal pain
- Fatigue
- Hepatomegaly
- Splenomegaly
- Diarrhea
- Cough
- Insomnia
- Anemia
- Malaise
- Pruritus
- Rash
- Vertigo
- Elevated AST
- Hypersensitivity to class/components
- Uncorrected electrolyte abnormalities
- Congenital long QT syndrome
- QT prolongation
- QT prolongation family history
- Torsades de pointes history
- Ventricular arrhythmia
- Bradycardia
- Recent MI
- CHF
- Carbamazepine
- Cisapride
- Dronedarone
- Fluconazole
- Fosphenytoin
- Levoketoconazole
- Mitotane
- Pentobarbital
- Phenobarbital
- Phenytoin
- Posaconazole
- Primidone
- Rifabutin
- Rifampin
- Thioridazine
Drug Status
| Availability | Prescription only |
| Pregnancy | Contraindicated |
| Breastfeeding | Can be used in infants >5kg |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Artefan | 20mg/120mg | Tablet | 12’s, 18’s, 24’s | Ajanta Pharma | Harley’s Ltd |
| Artefan | 60mg/360mg | Tablet | 6’s | Ajanta Pharma | Harley’s Ltd |
| Artefan | 40mg/240mg | Tablet | 12’s | Ajanta Pharma | Harley’s Ltd |
| Artefan | 80mg/480mg | Tablet | 6’s | Ajanta Pharma | Harley’s Ltd |
| Artefan | 180mg/1080mg | Suspension | 60mL | Ajanta Pharma | Harley’s Ltd |
| Artefan Dispersible | 20mg/120mg | Tablet | 6’s | Ajanta Pharma | Harley’s Ltd |
| Coartem | 20mg/120mg | Tablet | 12’s, 18’s, 24’s | Novartis Pharma | Novartis Kenya |
| Coartem | 80mg/480mg | Tablet | 6’s | Novartis Pharma | Novartis Kenya |
| Coartem | 20mg/120mg | Orodispersible tablet | 6’s | Novartis Pharma | Novartis Kenya |
| Coartesiane | 360mg/2160mg | Suspension | 120mL | Novartis Pharma | Novartis Kenya |
| Coartesiane | 180mg/1080mg | Suspension | 60mL | Novartis Pharma | Novartis Kenya |
| Co-Artesiane | 180mg/1080 mg | Suspension | 60mL | Dafra Pharma | Energia Pharm |
| Co-Artesiane | 180mg/1080 mg | Suspension | 100mL | Dafra Pharma | Energia Pharm |
| Co-Corither | 180mg/1080mg | Suspension | 60mL | Signature Healthcare | Signature Healthcare |
| Co-Corither DS | 80mg/480mg | Tablet | 6’s | Signature Healthcare | Signature Healthcare |
| Co-Malather | 20mg/120mg | Tablet | 24’s | Shelys Pharma | Beta Healthcare |
| Co-Malather | 80mg/480mg | Tablet | 6’s | Shelys Pharma | Beta Healthcare |
| Combiart-DT | 20mg/120mg | Tablet | 24’s | Strides Pharma | Universal Corporation |
| Falcized | 20mg/120mg | Tablet | 24’s | Zawadi Healthcare | Zawadi Healthcare |
| Lamitar AM | 20mg/120mg | Tablet | 24’s | Ind-Swift Ltd | Ind-Swift Ltd |
| Lartem | 180mg/1080 mg | Suspension | 24’s | Skant Healthcare | Skant Healthcare |
| Lartem | 20mg/120mg | Tablet | 24’s | Skant Healthcare | Skant Healthcare |
| Lartem Forte | 80mg/480mg | Tablet | 6’s | Skant Healthcare | Skant Healthcare |
| Lonart | 20mg/120mg | Suspension | 60mL | Bliss GVS | Prunus Pharma |
| Lufenart | 20mg/120mg | Tablet | 24’s | Umedica Labs | Unisel Ltd |
| Lufenart | 15mg/90mg | Suspension | 60mL | Umedica Labs | Unisel Ltd |
| Lonart | 20mg/120mg | Tablet | 24’s | Bliss GVS | Prunus Pharma |
| Lonart DS | 80mg/480mg | Tablet | 6’s | Bliss GVS | Prunus Pharma |
| Lonart DT | 20mg/120mg | Orodispersible tablet | 6’s | Bliss GVS | Prunus Pharma |
| Lonart Forte | 40mg/240mg | Tablet | 12’s | Bliss GVS | Prunus Pharma |
| Lufanate | 180mg/1080mg | Suspension | 60mL | Cosmos Ltd | Cosmos Ltd |
| Lufanate | 20mg/120mg | Tablet | 24’s | Cosmos Ltd | Cosmos Ltd |
| Lufanate Dispersible | 20mg/120mg | Orodispersible tablet | 6’s, 12’s | Cosmos Ltd | Cosmos Ltd |
| Lum-Artem | 20mg/120mg | Tablet | 24’s | Dawa Ltd | Dawa Ltd |
| Lum-Artem | 15mg/90mg per 5mL | Suspension | 60mL | Dawa Ltd | Dawa Ltd |
| Lum-Artem Forte | 80mg/480mg | Tablet | 6’s | Dawa Ltd | Dawa Ltd |
| Lumerax | 80mg/480mg | Tablet | 6’s | IPCA Labs | Sai Pharma |
| Lumiter DT | 20mg/120mg | Orodispersible tablet | 24’s | Macleods Pharma | Sai Pharma |
| Luteriam | 20mg/120mg | Tablet | 24’s | Square Pharma | Ace Pharma |
| Malarate | 20mg/120mg | Tablet | 24’s | Laboratory & Allied | Laboratory & Allied |
| Medistan-AL | 20mg/120mg | Tablet | 6’s, 12’s 18’s | Regal Pharma | Regal Pharma |
| Pro-Fantrine Forte | 80mg/480mg | Tablet | 6’S | Korlyns Therapeutics | Korlyns Therapeutics |
| Pro-Fantrine Forte | 180mg/1080mg | Suspension | 60mL | Korlyns Therapeutics | Korlyns Therapeutics |
| Shal’artem | 20mg/120mg | Tablet | 24’s | Shalina Labs | Shalina Healthcare |
| Shal’artem | 180mg/1080 mg | Suspension | 60mL | Shalina Labs | Shalina Healthcare |
| Shal’artem | 20mg/120mg | Orodispersible tablet | 18’s | Shalina Labs | Shalina Healthcare |
| Shal’artem | 20mg/120mg | Tablet | 24’s | Shalina Labs | Shalina Healthcare |
| Shal’artem | 180mg/1080mg | Suspension | 60mL | Shalina Labs | Shalina Healthcare |
| Shal’artem Forte | 80mg/480mg | Tablet | 6’s | Shalina Labs | Shalina Healthcare |
| Temtrin | 20mg/120mg | Tablet | 24’s | Crown Healthcare | Crown Healthcare |