• GERD:
    • Symptomatic non-erosive:
      • PO 20mg OD *4-8 weeks OR IV 20mg OD *7-10 days
  • Short-term treatment of erosive esophagitis:
    • Adult: PO 40mg OD *4-8 weeks OR IV 40mg OD *7-10 days
    • 15kg-<40 kg (>5 years): PO 20mg OD *8/52
    • ≥40kg(>5 years): PO 40mg OD *8/52
  • Maintenance treatment of erosive esophagitis:
    • PO 20-40mg
  • Hypersecretory conditions e.g. Zollinger-Ellison Syndrome:
    • PO 40mg BD OR initially IV 80mg BD, then may increase dose to 80mg TDS
  • Peptic ulcer disease (Off-label):
    • Duodenal ulcer: PO 40mg OD *2/52
    • Gastric ulcer: PO 40mg OD *4/52
  • Upper GI bleeding (Off-label):
    • Initially IV 80mg *1 then 8mg/hour *72 hours
  • pylori infection as part of multi-drug regimen (Off-label):
    • Adults: PO 40mg BD *10-14 days
    • 15-24kg: PO/NG 40mg BD*10-14 days
    • 25-34kg: PO/NG 60mg BD *10-14 days
    • >35kg: PO/NG 80mg BD*10-14 days
  • Tablet/Capsule:
    • 20mg
    • 40mg
  • Injection:
    • 20mg
    • 40mg
  • Switch IV patients to PO as soon as able to take tablets
  • Taken at least 30 min before meals

Proton Pump Inhibitor (PPI)

It binds to H+/K+-exchanging ATPase (proton pump) in gastric parietal cells, resulting in blockage of acid secretion

  • Headache
  • Diarrhea
  • Thrombophlebitis (IV use)
  • Abdominal pain
  • Nausea
  • Vomiting
  • URI symptoms (peds patients)
  • Fever (peds patients
  • Rash (peds patients)
  • Dizziness
  • Flatulence
  • Arthralgia
  • Elevated LAT/AST
  • Vitamin B12 deficiency (long-term use)
  • Fundic gland polyps (long-term use)
  • Hypersensitivity to components/class
  • Erlotinib
  • Mavacamten
  • Nelfinavir
  • Rilpivirine

                          Drug Status

Availability Prescription or OTC
Pregnancy Category B; weigh risk vs benefit
Breastfeeding weigh risk vs benefit
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Demopan 40mg Tablet 100’s The Relax Biotech Tata Africa
Luganor 40mg Injection 1’s Arwan Pharma Goodman Agencies
Pan 20mg Tablet 30’s Alkem Labs Pharmacor Ltd
Pan 40mg Tablet 30’s Alkem Labs Pharmacor Ltd
Pan IV 40mg Injection 1’s Alkem Labs Pharmacor Ltd
Panopaz 40mg Tablet 10’s Aglowmed Ltd Sai Pharma
Panpure 20mg Injection 1’s Emcure Pharma Lazor Pharma
Panpure 20mg Tablet 10’s Emcure Pharma Lazor Pharma
Pansalve 20mg Tablet 10’s Emcure Pharma Lazor Pharma
Pansec DR 40mg Tablet 28’s Ranbaxy Labs Surgilinks Ltd
Pantakind 40mg Tablet 60’s Mankind Pharma Pharma Specialities
Pantaz 40mg Tablet 50’s Medley Pharma Zawadi Healthcare
Pantel 40mg Capsule 30’s Shambhuprasad and Sons Zike Corporation
Pantin 20mg Tablet 30’s Hetero Labs Unisel Ltd
Pantin 40mg Tablet 30’s Hetero Labs Unisel Ltd
Panto 40mg Tablet 10’s Dawa Ltd Dawa Ltd
Panto-Denk 20mg Tablet 28’s Denk Pharma Laborex Kenya
Panto-Denk 40mg Tablet 28’s Denk Pharma Laborex Kenya
Pantocid 20mg Tablet 50’s Sun Pharma Sun Pharma
Pantocid 40mg Tablet 50’s Sun Pharma Sun Pharma
Pantocid 40mg Injection 1’s Sun Pharma Sun Pharma
Pantoloc 20mg Tablet 28’s Takeda Ltd Phillips Therapeutics
Pantoloc 40mg Tablet 14’s Takeda Ltd Phillips Therapeutics
Pantoloc 40mg Injection 5’s Takeda Ltd Phillips Therapeutics
Pantonex DR 40mg Tablet 30’s IPCA Labs Sai Pharma
Pantotab 40mg Tablet 30’s Micro Labs Micro Labs
Pantozed 40mg Injection 1’s Zawadi Healthcare Zawadi Healthcare
Pantro 40mg Injection 1’s Brawn Labs Sai Pharma
Pantro 40mg Tablet 30’s Brawn Labs Sai Pharma
Pasopan 40mg Tablet 10’s PSA International Avacare Kenya
Pentalink 40mg Tablet 30’s Lincoln Pharma C/O Medox Pharma Medox Pharma
Reprat 20mg Tablet 20’s Delorbis Pharma Europa Healthcare
Reprat 40mg Tablet 20’s Delorbis Pharma Europa Healthcare
Topraz 20mg Tablet 30’s Aurobindo Pharma Simba Pharma
Topraz 40mg Injection 1’s Aurobindo Pharma Simba Pharma
Trupan 40mg Injection 1’s Square Pharma Ace Pharma
Ultop 20mg Tablet 100’s Leben Labs Unisel Ltd
Ultop 40mg Tablet 100’s Leben Labs Unisel Ltd