- Elevated intracranial pressure associated with cerebral edema:
- IV 0.25-2g/kg/dose *1
- May be repeated every 6-8 hours as needed
- Elevated intraocular pressure:
- IV 1.5-2g/kg/dose *1, 30-60 min before surgery
Infusion: 20%
- To be administered over 30-60 minutes
- NOT to be admixed with other drugs.
Osmotic diuretic
It elevates the glomerular filtrate osmolarity, by hindering the tubular reabsorption of water and enhancing excretion of sodium and chloride reducing pressure
- Pulmonary congestion
- Edema
- Fluid and electrolyte imbalances
- Acidosis
- Polyuria
- Oliguria
- Metabolic acidosis
- Anuria
- Seizures
- CNS depression
- Thrombophlebitis at site of injection
- Coma
- Acute renal failure
- Thirst
- Dizziness
- Chest pain
- Tachycardia
- Hypersensitivity to components/class
- Anuria
- Pulmonary edema
- CCF
- Severe hypovolemia
- Active intracranial bleeding, except during craniotomy
- Pulmonary congestion or edema
- Tobramycin
Mannitol (distributed by Medisel), Mannitol (Amanta), Osmosol (Beximco), Osmosteril (Infusion)
Drug Status
Availability | Prescription only |
Pregnancy | Category C |
Breastfeeding | Caution advised |
Schedule | Not controlled |
BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
---|---|---|---|---|---|
Mannitol | 20% w/v | Injection | 500mL | Claris Otsuka | Reddys Pharma |
Mannitol | 20% w/v | Injection | 500mL | Amanta Healthcare C/O Surgilinks | Surgilinks Ltd |
Mannitol | 20% w/v | Injection | 500mL | Medisel Kenya | Medisel Kenya |
Osmosol 20 | 20% w/v | Injection | 500mL | Beximco Pharma | Madawa Pharma |