• Complicated intra-abdominal infections:
    • PO/IV 400 mg OD * 5-14 days 
  • Acute bacterial sinusitis (reserve for patients who have no other treatment options):
    • PO/IV 400 mg OD * 5-10 days 
  • Acute exacerbation of chronic bronchitis(reserve for patients who have no other treatment options):
    • PO/IV 400 mg OD  *5/7 
  • Bacterial skin & soft tissue infections:
    • PO/IV 400mg OD *7-21 days 
  • Treatment & prophylaxis of plague:
    • PO/IV 400mg OD * 10-14 days 
  • Active TB as part of a multi-drug regimen (Off-label):
    • PO 400 mg OD
  • Tablet:
    • 400mg
  • Injection:
    • 400mg/250mL
    • 4mg/100mL
  • IV infusion does not need further dilution.
  • Infuse over 1 hour
  • Do not admix with other drugs or infuse in same tubing simultaneously

Fluoroquinolone.

It inhibits subunits of DNA gyrase interfering with bacterial DNA replication and transcription.

  • Nausea
  • Diarrhoea
  • Dizziness
  • Agranulocytosis
  • Pancytopenia
  • Hearing impairment
  • Loss of vision
  • Anaphylactic reactions
  • Psychotic reactions
  • Migraines
  • Tremor
  • Confusion
  • Convulsions
  • Hypersensitivity to class/compounds
  • Patients >60 years
  • Patients <18 years- safety not established
  • Mysthaenia gravis
  • Uncorrected electrolyte abnormalities
  • QT prolongation
  • Congenital long QT syndrome
  • Ventricular arrhythmias
  • Bradycardia
  • Recent MI
  • History of aortic aneurysm (unless no other options)
  • Aortic aneurysm risk (unless no other options)

WARNING

  • Discontinue IMMEDIATELY in case of: tendinitis, peripheral neuropathy and CNS effects.
  • Indapamide
  • Pentamidine
  • Procainamide
  • Quinidine
  • Sotalol
  • Disopyramide

                                   Drug Status

Availability Prescription only
Pregnancy Category B3; Contraindicated
Breastfeeding Unknown; Not recommended
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Avelox 400mg Tablet 5’s, 10’s Bayer Schering Bayer Schering
Avelox 400mg/250mL Injection 1’s Bayer Schering Bayer Schering
Biomox 400mg Tablet 12’s Bio-Labs Pharmweb Chemist
Floxsafe 400mg Tablet 5’s MSN Labs Simba Pharma
Mahaflox 400mg Tablet 5’s Mankind Pharma Pharma Specialities
Maxim 400mg Tablet 5’s, 7’s Jamjoon Pharma Specialities
M-Flox 400mg Tablet 10’s Hetero Labs Unisel Ltd
Micromox 400mg Tablet 10’s Micro Labs Micro Labs
Micromox 400mg/100mL Injection 1’s Micro Labs Micro Labs
Molox 400mg Tablet 5’s CCL Pharma Harley’s Ltd
Moxeque 400mg Tablet 5’s Questa Care C/O Surgilinks Ltd Surgilinks Ltd
Moxsoft 0.5% w/v Eye Drops 5mL Alembic Pharma Europa Healthcare
Moxi-Bio 400mg Tablet 5’s Sava Healthcare C/O Medox Pharma Medox Pharmaceuticals
Moxicip 400mg Tablet 5’s Cipla Ltd Imperial Managed
Moxicip 400mg/100mL Injection 1’s Cipla Ltd Imperial Managed
Moxidoc 400mg Tablet 10’s Medisel Kenya Medisel Kenya
Moxiget 400mg Tablet 5’s Getz Pharma Surgipharm Ltd
Moximac 400mg Tablet 5’s Macleods Pharma Sai Pharma
Mupiban 2% w/w Cream 15g Biopharma Ltd Biopharma Ltd
Mupiban 2% w/w Ointment 15g Biopharma Ltd Biopharma Ltd
Plenmoxi 400mg Injection 1’s Unosource Pharma Unisel Ltd
Plenmoxi 400mg Tablet 10’s Unosource Pharma Unisel Ltd
Zeebact 400mg Tablet 5’s Zest Pharma Synermed Pharma