• Mild to moderate susceptible infections, throat infection, otitis media, cellulitis, pneumonia:
    • IM/slow IV/infusion: 6–1.2 g every 6 hours. May be increased in more serious infections.
  • Endocarditis (in combination with other antibacterial if necessary):
    • Slow IV/infusion: 2 g every 4 hours. If necessary increased to 2.4 g every 4 hours.
  • Meningitis, meningococcal disease:
    • Slow IV/infusion: Adult: 4 g every 4 hours
    • Infusion:
      • Neonate up to 7 days: 50 mg/kg every 12 hours.
      • Neonate 7 days to 28 days: 50 mg/kg every 8 hours.
      • Child: 50 mg/kg every 4–6 hours (max. per dose 2.4 g every 4 hours) 
  • Anthrax (in combination with other antibacterials):
    • Slow IV/infusion: Adult: 4 g every 4 hours

Injection: 5 MU, 1 MU

1mg of Pen G= 1,667 units

  • Single doses over 1.2 g given IV only.
  • Intra-thecal injection NOT recommended.

Penicillin.

Bactericidal. It inhibits the synthesis of the bacterial cell wall thereby causing cell death.

  • Urticaria
  • Anaphylaxis
  • Injection site pain
  • Diarrhoea
  • Jarisch-Herxheimer reaction
  • Fever
  • Angioedema
  • Joint pain
  • Haemolytic anaemia
  • Neutropenia
  • Hypersensitivity to penicillins
  • Probenecid prolongs half-life. May be used for this purpose.
  • Chloramphenicol
  • Tetracyclines
  • Attenuated live vaccines
  • Enoxaparin
  • Fondaparinux

                                   Drug Status

Availability Prescription only
Pregnancy Category A; Can be used
Breastfeeding Safe to use
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Benzapene 1 1 MU Injection 1’s Crown Healthcare Crown Healthcare
Benzapene 5 5 MU Injection 1’s Crown Healthcare Crown Healthcare
Benzyl penicillin G 1 MU Injection 1’s CSPC Zhongnuo Ray Pharma
Benzyl penicillin G sodium 5 MU Injection 1’s Ray Pharma Ray Pharma
Carepenlin 1 MU Injection 10’s Careplus Ltd Careplus Ltd
Fortified Procaine Penicillin 1 MU Injection 1’s Medisel Kenya Medisel Kenya
Medipen 5 MU Injection 1’s Medisel Kenya Medisel Kenya
Medipen 1 MU Injection 1’s Medisel Kenya Medisel Kenya