- Hypertension in patients whose blood pressure has been stabilized on losartan and hydrochlorothiazide given separately in the same portion.
Initial: 1 tab OD
Not to exceed 100mg/25mg daily
Losartan potassium 50mg
Hydrochlorothiazide 12.5mg
- The anti-hypertensive effect is attained within 3 weeks after initiation of therapy.
- Best taken in the morning due to the diuretic effect of hydrochlorothiazide (peaks in 4 hours).
Losartan: Angiotensin-receptor blocker (ARB)
Hydrochlorthiazide: thiazide diuretic
- Abdominal pain
- Fatigue
- Edema
- Orthostatic hypotension
- Headache
- Dizziness
- Cough
- Dry mouth
- Skin rashes
- Anorexia
- Dyspnea
- Rhinitis
- Hypersensitivity to components or sulfonamides
- Anuria
- CrCl<10
- Severe renal failure
- Severe hepatic failure
- Alcohol
- Barbiturates
- Narcotics
- Hypoglycemics
- Cholestyramine
- Colestipol
- ACEIs
- Tacrolimus
Drug Status
| Availability | Prescription only |
| Pregnancy | Contraindicated |
| Breastfeeding | Contraindicated |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Alsartan H | 50mg/12.5mg | Tablet | 28’s | Aristo Pharma | Surgilinks Ltd |
| Angilock Plus | 50mg/12.5mg | Tablet | 30’s | Square Pharma | Ace Pharma |
| Angizaar H | 50mg/12.5mg | Tablet | 30’s | Micro Labs | Micro Labs |
| Bepsar Plus | 50mg/12.5mg | Tablet | 100’s | Nabiqasim Industries | Harley’s Ltd |
| Carditan H | 50mg/12.5mg | Tablet | 28’s | Cosmos Ltd | Cosmos Ltd |
| Cardoplus | 50mg/12.5mg | Tablet | 30’s | Eskayef Bangladesh | Umoja Pharma |
| CoLosar-Denk | 50mg/12.5mg | Tablet | 28’s | Denk Pharma | Laborex Kenya |
| CoLosar-Denk | 100mg/12.5mg | Tablet | 28’s | Denk Pharma | Laborex Kenya |
| Dawalor-H | 50mg/12.5mg | Tablet | 10’s | Dawa Ltd | Dawa Ltd |
| Lora-HC | 50mg/12.5mg | Tablet | 30’s | Sava Healthcare C/O Medox Pharma | Medox Pharma |
| Lortan H | 50mg/12.5mg | Tablet | 30’s | Galaxy Pharma | Galaxy Pharma |
| Losacar H | 50mg/12.5mg | Tablet | 30’s | Cadila Healthcare | Cadila Healthcare |
| Losacard H | 50mg/12.5mg | Tablet | 30’s | Fredun Pharma | Krishna Chemists |
| Losakind-H | 50mg/12.5mg | Tablet | 30’s | Mankind Pharma | Pharma Specialities |
| Losar-H | 50mg/12.5mg | Tablet | 30’s | Unichem Labs | Europa Healthcare |
| Losartas-HT | 50mg/12.5mg | Tablet | 30’s | Intas Pharma | Accord Healthcare |
| Losastal-HL | 50mg/12.5mg | Tablet | 100’s | Medox Pharma | Medox Pharma |
| Losatec H | 50mg/12.5mg | Tablet | 30’s | RPG Life Sciences | Pharma Specialities |
| Losi-HT | 50mg/12.5mg | Tablet | 30’s | Nextgen Pharma | Nextgen Pharma |
| Lozart H | 50mg/12.5mg | Tablet | 30’s | Lords Healthcare | Lords Healthcare |
| Normozide | 50mg/12.5mg | Tablet | 10’s | CCL Pharma | Harley’s Ltd |
| Nusar H | 50mg/12.5mg | Tablet | 30’s | Emcure Pharma | Lazor Pharma |
| Presartan-H | 50mg/12.5mg | Tablet | 28’s | IPCA Labs | Sai Pharma |
| Prosan HZ | 50mg/12.5mg | Tablet | 30’s | Beximco Pharma | Madawa Pharma |
| Repace H | 50mg/5mg | Tablet | 30’s | Sun Pharma | Sun Pharma |
| Reten H | 50mg/12.5mg | Tablet | 30’s | Zest Pharma | Synermed Pharma |
| Tozaar-H | 50mg/12.5mg | Tablet | 28’s | Torrent Pharma C/O Medox | Medox Pharma |
| Unizar-H | 50mg/12.5mg | Tablet | 28’s | Gracure Pharma | Medisel Kenya |
| Vazortan-H | 50mg/12.5mg | Tablet | 30’s | Medley Pharma | Zawadi Healthcare |
| Xartan 50H | 50mg/12.5mg | Tablet | 30’s | Crown Healthcare | Crown Healthcare |
| Zaart-H | 50mg/12.5mg | Tablet | 30’s | Cipla Ltd | Imperial Managed |
| Zyltan H | 50mg/12.5mg | Tablet | 30’s | Troikaa Pharma | Harley’s Ltd |